Malaria Research and Control

The paper identifies 401 sex and transmission-related gene functions in malaria parasites through genetic screens, revealing conserved fertility mechanisms across eukaryotes.

This study uses computational methods to analyze the mutational landscape of Plasmodium falciparum DHFR, revealing evolutionary pathways and co-evolving networks that contribute to antifolate resistance.

This study investigates the role of HCCS and HCC1S in cytochrome c and c1 biogenesis in malaria parasites, revealing their distinct specificities and essential functions in the mitochondrial electron transport chain.

This study identifies N3-pyridyl thiamine (N3PT) as a more potent antiplasmodial thiamine analogue than oxythiamine, with lower toxicity to human cells and effective in vivo activity against malaria parasites.

This study shows that latent cytomegalovirus infection reduces antibody responses to malaria infection and vaccination by altering Tfh cell subsets and their activation.

This study identifies PfDMT1 as a critical iron transporter in malaria parasites, showing its essential role in iron acquisition and its potential as a therapeutic target.

This paper develops a self-cooling, self-humidifying backpack to transport live adult mosquitoes over long distances in challenging field conditions, achieving high survival rates comparable to controlled environments.

This study identifies PfSET10 as a H3K18 methyltransferase in Plasmodium falciparum that regulates chromatin structure and is essential for intraerythrocytic development.

This study shows that PfSET10 is not required for var gene expression, antigenic variation, or blood stage parasite survival.

The paper shows that RNA Polymerase I inhibitors affect different Pol I-transcribed genes in Plasmodium falciparum by varying degrees, with some genes being much more sensitive than others.

This study uses human iPSC-derived neuronal cultures exposed to hemozoin to show activation of DNA damage, p38 MAPK, and neurodegenerative pathways similar to cerebral malaria.

This study investigates the role of anemia and tissue hypoxia in hyperlactatemia during severe malaria using a murine model and human samples.

This study shows that host 5-HT levels influence Plasmodium transmission in mosquitoes by modulating mitochondrial homeostasis and reactive oxygen species.

This study characterizes the spatial and temporal flight kinematics of Anopheles coluzzii swarms, showing stereotypic shape and density patterns and modeling swarm structure based on visual perception.

This study shows that PP7 is essential for early ring-stage development in Plasmodium falciparum but not for erythrocyte invasion.

The paper analyzes whole-genome-sequenced Plasmodium falciparum samples to understand gene deletions associated with malaria rapid diagnostic tests, identifying patterns of chromosomal rearrangements and duplication.

The paper introduces MoTissU-ExM, a method to expand mosquito tissues for visualizing malaria parasites, enabling ultrastructural analysis of both host and parasite structures.

This study investigates heterochromatin dynamics during early sexual development in Plasmodium falciparum, showing that major changes occur at stage II/III and that transcriptional changes precede heterochromatin modifications.

MOIRE, a Bayesian R package, jointly infers allele frequencies, multiplicity of infection (MOI) and within-host relatedness from SNP or polyallelic malaria genotypes, yielding a panel-portable effective MOI.

This study identifies DMT1 and a chromosome 12 locus, including FtsH1, as novel contributors to Plasmodium falciparum resistance to quinine, alongside the known pfcrt gene.

This study uses scRNA-seq to identify gene expression profiles of asexual and sexual merozoites in Plasmodium falciparum, revealing key genes involved in invasion and sexual commitment.

This study examines morphological changes in apicoplasts of P. falciparum persisters after drug treatment, finding that apicoplasts become enlarged and irregularly shaped during dormancy, with variations in shape and positioning over time.

This study details the division and segregation of mitochondria and apicoplasts in Plasmodium falciparum using imaging and microscopy techniques.

This study shows that RON11 is essential for the biogenesis of the second rhoptry in Plasmodium falciparum merozoites and is required for erythrocyte invasion.

The paper investigates insecticide resistance and population structure in Anopheles gambiae from southern DRC, finding high resistance and genetic differentiation between populations.

The paper quantifies hemoglobin consumption variability in Plasmodium falciparum-infected red blood cells and attributes it to non-genetic host cell differences.

This paper develops a nanopore sequencing method to distinguish recrudescence from new infections in antimalarial trials, achieving high sensitivity and specificity.

The paper develops a high-content imaging assay to identify Plasmodium liver stage protein synthesis inhibitors and identifies two quinoline-4-carboxamides with distinct antiplasmodial and translation inhibition profiles.

This study shows that apicoplast-derived isoprenoids are essential for GPI anchor biosynthesis in Plasmodium falciparum, which is critical for parasite egress and invasion.