Author

Alex H. Y. Chan

University of CambridgeORCID 0009-0006-7897-4560Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Alex von KriegsheimiD· 1 shared Andrea Coates· 1 shared Christopher John SchofieldiD· 1 shared E. Elizabeth PattoniD· 1 shared Finian J. LeeperiD· 1 shared Florian RambowiD· 1 shared Imam FathoniiD· 1 shared Jair Gonzalez Marques JúnioriD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Alex von KriegsheimORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyAntimicrobial Agents and ChemotherapyPeer-reviewedOct 29, 2024

Identification and characterization of thiamine analogues with antiplasmodial activity

Imam Fathoni, Terence C. S. Ho, Alex H. Y. Chan…·Kevin J. Saliba

This study identifies N3-pyridyl thiamine (N3PT) as a more potent antiplasmodial thiamine analogue than oxythiamine, with lower toxicity to human cells and effective in vivo activity against malaria parasites.

6 citations

humanmouse

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Cancer BiologyCell ReportsPeer-reviewedJul 1, 2024

ALDH1A3-acetaldehyde metabolism potentiates transcriptionalheterogeneity in melanoma

Yuting Lu, Jana Trávníčková, Mihaly Badonyi…·E. Elizabeth Patton

This study shows ALDH1A3 and ACSS2 coordinate acetaldehyde-acetyl-CoA metabolism with histone acetylation in melanoma, contributing to transcriptional heterogeneity and drug resistance.

21 citations

zebrafishproteomics

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