Topic · Public Health, Environmental and Occupational Health · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
943 papers
Mahendra Prajapat, Samridhi Pathak, Ricka Gauba…·Supreet Saini
The paper develops a stochastic model to study actin treadmill regulation in Plasmodium, focusing on maintaining filament size and understanding regulator interactions.
Simon G. Trevino, Standwell C. Nkhoma, Shalini Nair…·Ian H. Cheeseman
This paper develops a single-cell genomics protocol to reconstruct haplotypes of Plasmodium falciparum parasites and analyzes 48 cells from a malaria infection to estimate clonality and haplotype relatedness.
Alistair Miles, Chris S. Clarkson, Krzysztof Kozak…·Bronwyn L. MacInnis
The paper sequences genomes of 765 malaria vector mosquitoes to study genetic diversity and insecticide resistance.
Sha Joe Zhu, Jacob Almagro Garcia, Gil McVean
The paper develops a statistical method to deconvolve multiple Plasmodium falciparum strains from sequencing data, enabling detailed analysis of mixed infections.
Swamy Rakesh Adapa, Rachel A. Williamson Taylor, Chengqi C. Q. Wang…·Rays H. Y. Jiang
The paper identifies a transmission expression signature in P. vivax blood stage infection, showing early commitment to sexual stages and potential for earlier transmission compared to P. falciparum.
Hussein Molu Abkallo, Axel Martinelli, Megumi Inoue…·Richard Leighton Culleton
This paper introduces a method to identify genetic drivers of multiple phenotypes in malaria parasites by combining LGS, sequencing, and mathematical modeling, demonstrating its effectiveness in detecting novel alleles for growth rate and strain-specific immunity.
Theo Sanderson, Julian C. Rayner
Phenoplasm curates and integrates phenotypic data from gene disruptions in Plasmodium parasites, enabling cross-species comparisons of genetic effects.
Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens…·Elizabeth A. Winzeler
Whole genome sequencing reveals how Plasmodium falciparum evolves resistance to diverse compounds and identifies new antimalarial drug targets.
Ellen Miranda Leffler, Gavin Band, George Busby…·Malaria Genomic Epidemiology Network
The paper identifies a structural variant in GYPA and GYPB genes associated with reduced risk of severe malaria in sub-Saharan African populations.
Gustavo Coutinho Cerqueira, Ian H. Cheeseman, Stephen F. Schaffner…·Daniel E. Neafsey
The paper uses longitudinal genomic data from Plasmodium falciparum isolates in Thailand to identify genetic markers associated with artemisinin resistance, finding significant changes in SNPs beyond kelch13.
Daniel Zinder, Mary M. Rorick, Kathryn E. Tiedje…·Mercedes Pascual
The paper identifies single amino-acid polymorphisms in PfEMP1 homology blocks associated with severe malaria pathophysiology and disease outcomes.
Patrícia Brasil, Mariano Gustavo Zalis, Anielle de Pina-Costa…·Cláudio Tadeu Daniel‐Ribeiro
The paper identifies Plasmodium simium as the cause of malaria outbreaks in Rio de Janeiro, demonstrating zoonotic transmission from monkeys to humans.