Epilepsy research and treatment

The paper tests nine putative antiseizure drugs in a scn1lab zebrafish model of Dravet syndrome, finding none significantly suppress seizures in electrophysiology assays.

This study identifies optimal spatial and amplitude parameters for neurostimulation in a mouse seizure model, showing that higher amplitude stimulation at specific hippocampal regions significantly reduces epileptiform activity.

This study shows that early-life immune activation increases seizure risk in Nf1+/- mice but not wild-type mice, suggesting it as a risk factor for NF1-associated epilepsy.

The paper analyzes the Epileptor model using bifurcation theory to understand how parameter changes can produce different seizure types and how an additional mechanism affects its dynamics.

This study investigates changes in axo-axonic cells (AACs) in the dentate gyrus after status epilepticus, showing reduced synaptic inputs and altered firing properties that impair their inhibitory function.

This study investigates the role of VIP-expressing interneurons in the ventral subiculum in temporal lobe epilepsy, finding that their inhibition reduces seizures while their activation increases seizure frequency.

This study investigates the long-term effects of early-life seizures on hippocampal-prefrontal network function and behavior in rats, finding impaired connectivity and altered neurotransmission linked to cognitive and psychiatric-like symptoms.

This study shows that expressing LGI1 in LGI1-deficient neurons restores normal excitability by restoring Kv1.1 channel density and function at the axon initial segment.

This study investigates how loss of SCN1B affects neuronal function in the hippocampus of Scn1b knockout mice, revealing altered intrinsic excitability, synaptic properties, and information processing.

This study investigates the role of KNa1.1 channel changes in seizure susceptibility after traumatic brain injury, finding enhanced expression and altered distribution contribute to disrupted excitation-inhibition balance.

The paper uses a mathematical model to analyze EEG data from people with epilepsy and identifies cortisol levels and sleep stages as factors explaining daily variability in epileptiform discharges.

This study uses single-cell RNA sequencing in a Dravet syndrome mouse model to identify early transcriptomic changes and axonopathy in interneurons during epileptogenesis.

The paper uses fluorescent sensors to study glutamate and GABA dynamics during interictal spikes and seizures in a rodent model, revealing a progressive failure of inhibitory restraint leading to seizures.

The paper investigates DNA 5-hydroxymethylation (5-hmC) changes in TLE patients and a rat model, finding reduced 5-hmC levels and specific gene associations, with Tet1 manipulation affecting seizure outcomes.

This paper systematically reviews chemically-induced seizure models in zebrafish, identifying common chemoconvulsants and highlighting variability in protocols and reporting practices.

This study shows that enhancing NaV1.1 in Dravet syndrome patient neurons increases firing rates and reduces network synchrony using HD-MEAs.

This study investigates the association between rare non-coding deleterious variants and epilepsy, finding a significant link with genetic generalized epilepsy (GGE) but not with non-acquired focal epilepsy (NAFE).

This study investigates spinal cord pathology in a Dravet Syndrome mouse model and identifies dysregulated pathways related to monooxygenase activity, fatty acid ligases, and lactate transporters.

The paper identifies a protein complex containing Na+/K+ ATPase and Jus that prevents epileptogenesis in Drosophila by regulating neural activity.

This study shows that CRTC1 knockdown in marmosets leads to epileptic responses and abnormal cFOS expression, with associated neural activity changes and lesions.

This study examines how sex and gonadectomy affect seizure susceptibility and mortality in mice using a repeated low-dose kainic acid injection model.

This study investigates how remote brain regions influence epileptic activities in a mouse model, finding that the contralateral hippocampus is critical for sustained seizures but not transient spikes.

This study identifies miRNA-mRNA regulatory interactions in epilepsy using multi-omics data from six studies, revealing potential biomarkers like hsa-miR-27a-3p and target genes CABP1, SLC20A1, and SLC35G1.

This study evaluates on-demand low-frequency stimulation for seizure control in a mouse model of mesial temporal lobe epilepsy, showing improved efficacy and no cognitive deficits.

The paper investigates inhibitory deficits in the hippocampal CA2 region of a mouse model of temporal lobe epilepsy, identifying reduced cholecystokinin-expressing interneurons and impaired inhibition.

This study uses cell-type deconvolution and single-cell signatures to analyze bulk RNA-seq data from FCD patients, revealing subtype-specific cellular changes, including astrogliosis in FCD IIb.

This study identifies sex differences in mortality and seizure morbidity in Scn1a+/− mice, showing increased female mortality and male seizure severity, with hyperactivity possibly contributing to female mortality.

The paper shows that brief tofacitinib treatment suppresses seizures and reverses cognitive deficits in chronic epilepsy by targeting a resurgent JAK/STAT pathway activation.

This paper describes a novel mouse model of SLC6A1 mutation-associated neurodevelopmental epilepsy, showing seizure burden correlates with behavioral deficits and drug responses.

The paper identifies three causative genes for childhood epileptic encephalopathies through trio-based whole-exome sequencing and individualized analysis of genetic variants.