Epilepsy research and treatment

This study uses computational modeling and in vitro experiments to investigate how low-frequency electrical stimulation delays seizures by modulating ion dynamics and neuronal excitability in rat hippocampal slices.

This study uses a zebrafish model of cblX syndrome to show that mTor inhibition at moderate doses reduces seizure severity, but higher doses cause a refractory response in hcfc1a mutants.

DIME improves SOZ localization using iEEG data, achieving high recall and accuracy in predicting surgical outcomes.

This study shows that clearing senescent cells reduces seizures and improves memory in a mouse model of temporal lobe epilepsy and finds similar SC accumulation in human TLE patients.

This paper introduces a low-cost, high-fidelity epilepsy monitoring unit for long-term continuous recording of seizures and spreading depolarization in freely moving rats.

This paper uses a neural mass model to show how different dysfunctions cause seizures and how targeted interventions can terminate them effectively.

This study shows that loss of presenilin 2 function increases seizure susceptibility in young mice but not in aged mice, and reduces GluK5 expression in aged PSEN2 knockout mice.

This study investigates seizure occurrence in FCD type II by analyzing lesion position and cytoarchitectural changes in a mouse model.

This study generates mosaic depdc5 loss-of-function zebrafish models to study DEPDC5-related epilepsy and early death, finding increased seizure-like behavior and neuronal hyperexcitability.

This paper identifies novel epilepsy modifier genes in mice through meta-analysis of GWAS data and functional network analysis, highlighting genes involved in neurodevelopmental processes not targeted by current therapies.

The paper develops a protocol to characterize epileptogenic tissue using multimodal data from surgical samples, aiming to improve diagnosis and treatment of drug-resistant epilepsy.

This study analyzes thalamic seizure propagation patterns in patients with focal seizures, finding that the mediodorsal thalamus is frequently involved but not typically the first site engaged during seizure onset.

This study shows white matter signals during seizures reflect communication between brain regions and differentiate epilepsy pathophysiologies, challenging past assumptions about their limited value.

The paper finds elevated thalamic blood flow in children with SeLECTS compared to controls, with variations based on spike distribution and antiseizure medications.

This study shows NDNF+ interneurons regulate cortical excitability, with depolarization suppressing seizures and hyperpolarization exacerbating them, mediated by GABAB receptors.

This study uses supervised machine learning to automatically quantify seizure severity from video data in mice, enabling high-throughput and standardized seizure scoring.

The paper develops a probabilistic model to identify epileptogenic networks using interictal SEEG data, achieving high classification accuracy with a reduced feature space.

The paper uses EEG functional connectivity to track progression from infantile epileptic spasms syndrome to Lennox-Gastaut Syndrome and identifies patterns associated with treatment response and disease markers.

This study investigates cortical circuit dynamics in Ank3-1b-/- mice, showing disrupted excitatory-inhibitory balance and altered sensory processing, while some sensory functions remain preserved.

This study identifies patient-specific functional biomarkers in temporal lobe epilepsy using multimodal MRI data to predict clinical outcomes and guide precision therapeutics.

This study shows that daily intermittent fasting reduces seizure frequency and improves sociability in mouse models of absence epilepsy without adverse effects.

This study investigates a mouse model of PCDH19-clustering epilepsy, finding hyperthermia-induced seizures and reduced parvalbumin-expressing interneurons in specific brain regions.

This study shows that hyperreactive stress circuits in mice increase time-dependent SUDEP susceptibility through exaggerated autonomic reflexes following seizure induction.

The paper examines seizure initiation dynamics in temporal lobe epilepsy using in vivo two-photon calcium imaging, finding two distinct yet stable initiation pathways involving excitatory and inhibitory neurons.

This study develops a novel mouse model with Purkinje cell-specific Scn1b deletion, revealing cerebellar dysfunction and associated neurological impairments without early mortality.

This study investigates the role of Dlx-expressing interneurons in TLE, finding they are largely spared but show reduced activity, and that enhancing their activity can improve cognitive function.

The paper develops ImPheNet, a deep learning tool to classify phenotypes and assess drug toxicity in Dravet Syndrome brain organoids using live imaging data.

This study identifies splice-switching antisense oligonucleotides that correct splicing defects in SCN8A, reducing seizures and improving survival in a mouse model of genetic epilepsy.

This study shows that reduced spine density and weakened neck compartmentalization in FCD increase neuronal excitability, contributing to epileptogenesis beyond inhibitory deficits.

The paper identifies HIF1α as a regulator of CaV3.2 expression, linking hypoxia to neuronal hyperexcitability and epileptogenesis.