Epilepsy research and treatment

This study shows that reducing NeuroD2 activity in Xenopus laevis tadpoles causes seizure-like behavior, neuronal hyperactivity, and a leaky blood-brain barrier, supporting a haploinsufficiency model for DEE75.

This study identifies the cellular sources of ictal population signals in seizures using calcium imaging and electrophysiology in mouse models.

This study examines hippocampal activation and histopathological changes in CACNA2D2 knockout mice, finding altered functional activity without significant structural changes associated with seizure susceptibility.

This paper identifies mechanistic biomarkers for epileptogenicity using computational modeling and SEEG data, showing that combining biomarkers improves seizure zone localization and reveals extended pathological networks beyond the clinically identified seizure zone.

The paper shows that epileptic spikes during sleep block sleep spindle production in thalamic recordings of patients with epileptic encephalopathy.

The paper uses snRNA-seq to analyze mosaic chromosome 1q gain in a case of epilepsy with hyaline protoplasmic astrocytopathy, finding cell-type-specific gene expression changes in neurons and astrocytes.

This study shows that selectively lesioning GABAergic or cholinergic neurons in the medial septum of rats leads to behavioral changes and increased susceptibility to status epilepticus.

This study identifies presynaptic targets in the entorhinal-hippocampal circuit that effectively suppress seizures using low-frequency stimulation in a mouse model of MTLE.

This paper proposes an autoregressive modeling approach for identifying and controlling epileptic seizures using real data, showing effectiveness in attenuating seizures and driving signals to interictal stages.

This study identifies subregional cerebellar atrophy patterns in epilepsy syndromes using MRI data from 1,602 patients and 1,022 controls, finding significant volume loss in posterior lobe regions.

This study uses computational models to explore seizure onset and propagation in mice brains and identifies strategies to limit seizure spread.

The paper analyzes the expression patterns of epilepsy-associated genes across tissues and brain cell types, revealing distinct expression-phenotype correlations among gene classes.

This study identifies a link between hypothalamic orexin neuron activity and seizures in a mouse model and shows that targeting this activity with deep brain stimulation can reduce seizures.

This paper introduces an automated algorithm to detect seizure-related events in calcium imaging data, showing accurate detection of pre-ictal spikes and seizure wave propagation in mice.

The paper investigates cortical development in a rat model of Absence Epilepsy and finds that the transient hyperconnectivity from deep to superficial layers is absent, contributing to pathological neural dysfunctions.

This paper investigates how epilepsy patients respond to photic stimulation, finding differences in EEG biomarkers that suggest cortical excitability changes associated with seizure states.

The paper classifies molecular defects of six SLC13A5 mutations into two classes, revealing distinct mechanisms of impaired citrate transport and protein folding, with implications for targeted therapies.

This study uses hdEEG to assess excitation/inhibition balance in TLE patients, finding a correlation with cognitive function and gene expression.

This study investigates epigenetic changes in GABAergic development using DS iPSCs and shows that VPA can rescue some chromatin abnormalities.

This study identifies depth-dependent cortical microstructure alterations in children with focal epilepsy using quantitative MRI, suggesting potential pre-symptomatic changes detectable regardless of radiological abnormalities.

This study outlines the longitudinal epilepsy and developmental trajectories in STXBP1-related disorders using clinical and standardized assessments, revealing subgroup differences and informing future therapeutic strategies.

This paper evaluates gene therapy using Kv1.1 potassium channel overexpression in a mouse model of FCD, showing reduced seizures but no improvement in cognitive or behavioral issues.

This study identifies optimal spatial and amplitude parameters for neurostimulation in a mouse seizure model, showing that higher amplitude stimulation at specific hippocampal regions significantly reduces epileptiform activity.

This study investigates changes in axo-axonic cells (AACs) in the dentate gyrus after status epilepticus, showing reduced synaptic inputs and altered firing properties that impair their inhibitory function.

This study investigates the role of VIP-expressing interneurons in the ventral subiculum in temporal lobe epilepsy, finding that their inhibition reduces seizures while their activation increases seizure frequency.

This study investigates the long-term effects of early-life seizures on hippocampal-prefrontal network function and behavior in rats, finding impaired connectivity and altered neurotransmission linked to cognitive and psychiatric-like symptoms.

This study shows that expressing LGI1 in LGI1-deficient neurons restores normal excitability by restoring Kv1.1 channel density and function at the axon initial segment.

This study investigates how loss of SCN1B affects neuronal function in the hippocampus of Scn1b knockout mice, revealing altered intrinsic excitability, synaptic properties, and information processing.

The paper uses a mathematical model to analyze EEG data from people with epilepsy and identifies cortisol levels and sleep stages as factors explaining daily variability in epileptiform discharges.

The paper uses fluorescent sensors to study glutamate and GABA dynamics during interictal spikes and seizures in a rodent model, revealing a progressive failure of inhibitory restraint leading to seizures.