Xingqi Chen

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

The paper identifies a distinct peritumoral glioblastoma cell population with unique epigenetic and phenotypic features associated with poor patient outcomes.

The paper shows that RNA polymerase II pausing maintains chromatin organization in chicken erythrocytes by repositioning euchromatin and preserving paused promoters.

This paper introduces FFPE-ATAC, a method for profiling chromatin accessibility in formalin-fixed paraffin-embedded tissues, demonstrating its effectiveness with colorectal cancer samples.

The paper investigates extrachromosomal DNA (ecDNA) in gastric cardia adenocarcinoma, finding associations with chromothripsis, DNA damage, and prognosis based on oncogene amplicons.

The paper uses single-cell transcriptomics to identify MHCII-expressing keratinocytes in pressure ulcers linked to poor healing outcomes.

The paper identifies functionally distinct subgroups of glioblastoma stem cells (GSCs) by analyzing cross-species chromatin accessibility, showing that epigenetic regulation is controlled by developmental origin.

This study identifies a primed chromatin state in oligodendroglia that facilitates rapid activation of immune gene programs in multiple sclerosis.

This study uses super-resolution imaging to reveal the 3D structure and organizing mechanism of accessible chromatin domains.

The paper introduces Pi-ATAC, a method combining single-cell chromatin and proteomic profiling, revealing hypoxia's role in shaping the regulome in tumor cells.