Sperm and Testicular Function

This paper develops E-InfertilityTest, an explainable AI model to classify infertile versus fertile sperm using transcriptomic data and provides gene-level explanations for predictions.

This study identifies SPE-40/FAM187 as a conserved sperm protein essential for fertilization in C. elegans, showing that its mutation causes sub-fertility without affecting sperm production or motility.

This study shows that cholesterol-based extenders can cryopreserve beef and bison semen without equilibration, reducing processing time and maintaining sperm quality.

This study identifies SPARK as a conserved multi-protein complex essential for vertebrate fertilization, linking gamete recognition to membrane fusion.

This study identifies FIMP as a binding partner of TMEM95, determines their complex structure, and shows that disrupting this interaction inhibits sperm-egg fusion.

The paper introduces hSPICER, a functional assay to assess sperm fertilizing potential by measuring cell-cell fusion with hJUNO-expressing cells, showing correlation with in vitro fertilization outcomes.

The paper identifies a population of male germ cells in mice that exhibit non-apoptotic cell death characteristics during G0 arrest, suggesting selection based on cellular health for spermatogonial stem cell precursors.

This study uses deep learning with label-free imaging flow cytometry to automate bovine sperm morphology classification, achieving high accuracy and highlighting the need for standardized datasets.

The paper investigates functional and localization differences among orthologs of the Drosophila melanogaster essential gene gdrd, finding that some orthologs can rescue fertility while others cannot due to structural and physicochemical differences.

This study shows that SIRT7 maintains genome stability in aging mouse testes by regulating H3K36ac, preventing premature loss of spermatogonia and meiotic defects.

This paper develops a microfluidic device using surface engineering to selectively remove DNA-damaged sperm through antibody-mediated negative selection, improving sperm quality for assisted reproduction.

This study identifies MCT1 as a metabolic checkpoint regulator in spermatogenesis, showing its role in meiotic progression through epigenetic mechanisms.

This study shows that TENT5C regulates Odf1 poly(A) tail length, affecting sperm morphology and fertility by controlling ODF1 protein localization.

This study shows epididymal extracellular vesicles transfer mRNAs to sperm, which then influence early embryo gene expression.

This study identifies transcriptional states and regulators of spermatogonial stem cell differentiation in marmoset testes across developmental stages.

The paper shows SMG6 and PIWIL1 work together in the chromatoid body to regulate mRNAs via piRNA and NMD pathways, with SMG6's endonuclease activity aiding piRNA-guided degradation.

The paper defines metabolic programs during spermatogenesis by analyzing transcriptomic, proteomic, and metabolic changes across meiotic stages.

This study shows that THC exposure to postejaculatory sperm reduces motility, damages DNA, impairs acrosome integrity, alters the methylome, and decreases embryo development potential.

This study finds that cancer survivors have a higher prevalence of loss of Y chromosome in their spermatozoa compared to controls, suggesting it as a potential biomarker for genomic instability and disease risk.

This study evaluates a novel sperm capacitation technology, HyperBull, in bovine IVF and finds it increases hatched blastocyst rates compared to conventional methods.

This study shows that SPRY4-ERK signaling acts as a checkpoint to restore spermatogenesis after germline stem cell damage, with its loss leading to impaired regeneration and fertility.

The paper defines a 3D chromatin compartment blueprint that programs histone-to-protamine exchange during spermiogenesis using ATAC-seq, CUT&Tag, and Hi-C.

This study maps chromatin accessibility and protamine incorporation during spermiogenesis, revealing compartment-specific dynamics and their role in genome stability.

This study shows that acute paternal immune activation alters sperm small RNAs, which reprogram embryonic gene expression and enhance offspring survival from viral infection.

This study shows that glycogen metabolism in Sertoli cells supports germ cell colonization during early testis development through lactate production, highlighting a critical metabolic dependency.

This study investigates whether HSP90AA1 variants cause autosomal dominant male infertility in humans and finds that while some variants are associated with infertility, their pathogenicity remains uncertain.

The paper validates three TEX11 variants associated with human azoospermia by generating mouse models and observing fertility and spermatogenesis defects.

This study investigates how exercise-induced fatigue affects the male reproductive system and shows that MXRA7 reduces epididymitis by inhibiting pyroptosis.

This paper introduces a framework for evaluating sperm trajectory tracking in crowded microscopy videos to improve automated motility analysis.

The paper develops a sperm-based bioassay using motility parameters to diagnose cardiovascular and cerebrovascular diseases with high accuracy.