SARS-CoV-2 and COVID-19 Research

This study examines how RBD mutations in SARS-CoV-2 affect adsorption to hydrophobic and hydrophilic surfaces, revealing structural deformations and distinct landing-footprints.

The paper reports the first cases of SARS-CoV-2 seropositivity in Eurasian fallow deer, showing increased seroprevalence with emerging variants.

The paper uses hamster sera from variant-specific infections to map antigenic differences among SARS-CoV-2 variants, revealing significant antigenic variation among Omicron subvariants.

This study investigates the inhibition of coronaviral main proteases by PF-00835231, showing broad-spectrum activity and providing structural insights into its binding modes.

This paper presents an optimized protocol for generating spike trans-complemented SARS-CoV-2 replicons with single-cycle infectivity in BSL-2 settings.

The paper identifies SARS-CoV-2 genetic markers associated with host domestication using a k-mer-based pipeline, revealing mutations and host-specific genomic patterns.

This study maps immunodominant sites on MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans, showing peak neutralizing activity against S1 and RBD epitopes.

This study investigates how SARS-CoV-2 nsp14 proofreading affects nucleoside antiviral activity using genetic and pharmacological methods, finding that nsp14 attenuation increases sensitivity to nucleoside analogues.

This paper uses D-NEMD simulations to study how the fatty acid site in the glycosylated SARS-CoV-2 spike modulates its structure and function, revealing allosteric networks and the role of glycans.

The paper uses Deep Mutational Scanning to analyze SARS-CoV-2 PLpro mutations, identifying functional residues and drug-escape variants.

This paper develops a vaccine strategy using immunologically orthogonal protein nanoparticles to focus antibody responses on a specific SARS-CoV-2 RBD epitope.

The study shows that SARS-CoV-2 S protein undergoes a conformational change at the Golgi complex, forming epitopes recognized by virus-neutralizing antibodies in the S1 subunit.

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

This study shows that SARS-CoV-2 mAb treatment shifts memory B cell epitope recognition, affecting their response to vaccination.

The paper investigates the evolutionary origins of the BA.2.86 SARS-CoV-2 variant, finding it evolved through multiple transmission chains and recombination, not a single chronic infection.

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

This study evaluates neutralization resistance, infectivity, and membrane fusion of JN.1-derived SARS-CoV-2 subvariants SLip, FLiRT, and KP.2, identifying key mutations affecting antibody sensitivity and spike function.

This study shows that a third mRNA COVID-19 vaccine dose increases IgG4+ memory B cells and Omicron subvariant recognition, but only in those primed with mRNA, not adenovirus.

The paper uses statistical and machine learning methods to analyze how sex and age influence antibody responses to SARS-CoV-2 infection and vaccination.

This study identifies critical human host factors involved in SARS-CoV-2 multicycle replication through a genome-scale siRNA screen and validates potential antiviral targets.

This study identifies the dominant modes of SARS-CoV-2 shedding in the human respiratory tract across different infection phases using metagenomic data and a novel algorithm.

This paper shows that protein language models can assess mutation effects in SARS-CoV-2 spike protein without multiple sequence alignments, capturing evolutionary constraints and variant properties.

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

This study determines the structure of HKU1 spike RBD bound to TMPRSS2, identifies host receptor usage determinants, and shows the role of antibodies and glycan shielding in neutralization.

This paper presents a bioelectronic platform that recreates viral infection steps to identify distinct fusion signatures of SARS-CoV-2 variants of concern.

This study determines the structure of HKU1-CoV receptor binding domain in complex with TMPRSS2, identifying key residues for host tropism and revealing the structural basis of TMPRSS2 activation.

This study uses deep mutational scanning to assess how mutations in SARS-CoV-2 spike proteins affect ACE2 binding, cell entry, and serum escape, linking these effects to clade growth rates.

This study identifies virapinib, a novel inhibitor of macropinocytosis that blocks viral entry by SARS-CoV-2, Monkeypox virus, and TBEV without host cell toxicity.

This study identifies host proteins incorporated into HCoV-OC43 virions and virus-modulated extracellular vesicles, revealing their roles in viral spread and extracellular vesicle composition.

This study examines how temperature affects Spike-ACE2 interactions in Omicron subvariants and links these interactions to viral transmission efficiency.