Mosquito-borne diseases and control

This paper introduces a modified forced oviposition method for Culex quinquefasciatus and Aedes aegypti, showing that smaller containers increase oviposition rates and that the method is effective for generating F1 progeny for vector research.

This study shows that G-CSF protects against arthritogenic alphavirus disease through type I IFN signaling in mice.

The study evaluates the effectiveness of the Sterile Insect Technique (SIT) in reducing Aedes aegypti populations on Captiva Island, Florida, showing up to 79% adult population reduction and 59% egg density decline, but highlighting challenges from wild female influx.

This study identifies metabolic reprogramming of sulfur recycling via MTA and Mat2a as a key driver of CHIKV infection and highlights potential therapeutic targets.

This study characterizes mosquito diversity and arbovirus circulation in Taï National Park, western Cote d'Ivoire, identifying key species and virus hotspots.

The paper investigates how arboviruses like chikungunya virus maintain persistent infections in mosquito cells through translational repression of viral RNA without affecting host cell fitness.

This study adjusts laboratory methods to better manipulate field-derived Aedes aegypti mosquitoes, improving blood feeding and fertilization monitoring techniques.

This study identifies ER subdomain localization and membrane proximity as determinants of orthoflavivirus protease cleavage efficiency and shows sequence specificity affects viral fitness.

This study analyzes pooled Ct values from mosquito surveillance to estimate infectious mosquito prevalence, showing that Ct values reflect biologically meaningful variation and can improve transmission risk estimates.

The paper identifies early T and NK-cell dysfunction in dengue patients that predicts severe disease, with obesity exacerbating these signatures.

This study shows mosquito immune cells help spread dengue and Zika viruses in Aedes aegypti, supporting a 'trojan horse' model of virus dissemination.

This study examines how heatwaves affect different developmental stages of Aedes albopictus, revealing stage-specific impacts on survival, development, and microbiota.

This study maps the single-cell transcriptional and metabolic changes in Aedes aegypti midgut and fat body after a bloodmeal, revealing diverse cell populations and a novel fat body-yolk cell type.

This study examines the B cell receptor repertoire and antibody responses after 17DD-YF vaccine boosting, finding a transient antibody response with limited neutralization capacity and rapid clonal expansion of IgA and IgG isotypes.

This paper identifies Emetine dihydrochloride as a potent antiviral against Chikungunya virus, showing reduced viremia and absence of joint swelling in mice.

This study identifies mRNA 3'-end processing protein complexes as interactors of DENV NS3 and shows their presence, not enzymatic activity, is critical for DENV replication.

The paper reports the complete CDS of five viruses detected in mosquitoes from Reunion Island, including a protoambidensovirus previously reported only in C. pipiens found in A. albopictus.

This study identifies sphingomyelins in mosquito salivary extracellular vesicles that enhance flavivirus transmission by altering the host lipidome and increasing viral protein levels.

The paper identifies orally bioavailable inhibitors of the Zika virus NS2B-NS3 protease that show antiviral activity in vitro and reduce viral RNA load in a murine infection model.

This study engineers outer membrane vesicles displaying dengue EDIII antigens to elicit strong, serotype-specific immune responses and neutralizing antibodies against all four dengue serotypes.

This paper uses disaggregation regression to predict dengue incidence in Africa from aggregated data, showing better alignment with reported cases than environmental suitability models.

This study shows that parental exposure to wet and dry conditions affects egg viability, thermotolerance, and nutrient composition in Aedes aegypti.

This study examines how prolonged dehydration stress affects Mayaro virus infection and vector competence in Aedes aegypti mosquitoes, finding that dehydration alters viral dissemination dynamics.

This study identifies key factors regulating JEV replication differences in human and porcine macrophages through multi-omics analysis and functional validation.

The paper shows that larval environment affects adult mosquito traits and disease transmission through molecular and phenotypic changes.

The paper maps YFV interactomes in human and mosquito cells, identifies RBBP6 as a restriction factor, and reveals divergent host interaction strategies among flaviviruses.

The paper uses metagenomics to survey mosquito vectors in Burkina Faso, detecting Sindbis virus for the first time in the region and identifying a new potential vector species.

This study examines the thermotolerance of mosquito eggs and adults from Aedes species, finding that human-associated lineages have higher egg viability under high-temperature stress.