Mosquito-borne diseases and control

Dengue Virus Serotype 2 Infection Transcriptionally Reprograms Host Neutrophils to Establish an Immunosuppressive Microenvironment in Mice

This study shows that Dengue virus serotype 2 reprograms neutrophils in mice to create an immunosuppressive environment, with FGL2-expressing neutrophils playing a key role.

Climate change and extreme weather events to intensify West Nile virus activity

The paper develops spatial models to predict West Nile virus activity in Arizona using mosquito data and weather patterns, finding drought-monsoon cycles drive outbreaks and climate change will intensify them.

Chikungunya virus live-cell reporter systems reveal cell-type-dependent antiviral responses to ribavirin

This study develops live-cell CHIKV reporter systems to analyze cell-type-dependent antiviral responses to ribavirin, revealing differences in antiviral efficacy across cell models.

A broadly active flavivirus NS4B targeting compound that blocks NS4B-NS3 binding and replication organelle formation

This paper identifies SRI-38841, a xanthine analog that inhibits multiple flaviviruses by blocking NS4B-NS3 interaction and replication organelle formation.

Drivers of mosquito presence and abundance in urban and garden ponds in a European city

The paper investigates mosquito presence and abundance in urban and garden ponds, finding that fish presence negatively affects mosquitoes, while urbanization has a minor role.

Single-Cell Transcriptomic Analysis of the Immune Response to CHIKVInfection

This study uses scRNA-seq to analyze the immune response to CHIKV infection, finding increased monocytes and dendritic cells, and a strong interferon response driven by monocytes.

Coevolutionary constraints of Zika virus nonstructural protein 5 replication and interferon antagonism activities

This study identifies evolutionary constraints linking Zika virus NS5 replication and interferon antagonism by analyzing fitness landscapes and attenuation in mice.

Systematic genome analysis enables long-overdue taxonomic reorganization of genus Orthoflavivirus; potential assignment of over 50 new species

The paper proposes a genetic divergence threshold for demarcating orthoflavivirus species, identifying 25 new Euflavivirus and 33 new Fusivirus species.

Engineering Upd-like to broadly restrict arbovirus infection and vector competence in mosquitoes

This study identifies Upd as an activator of JAK/STAT signaling in mosquitoes that restricts arbovirus infection and reduces vector competence.

Single-cell analysis of West Nile virus infection in brain organoids identified a serine synthesis enzyme as a determinant of viral neural tropism and a druggable antiviral target

This study uses human cerebral organoids to identify PHGDH as a key metabolic factor enabling WNV infection and a potential drug target.

Development of a Synthetic Genomics-Based Venezuelan Equine Encephalitis Virus Expressing Secreted Gaussia Luciferase for High-Throughput Antiviral Screening

This paper develops a synthetic VEEV reporter virus for high-throughput antiviral screening, identifying inhibitors of VEEV replication using FDA-approved compounds.

Entomological investigations into yellow fever outbreak in northern Ghana

The paper investigates mosquito vectors during a yellow fever outbreak in Ghana, finding high transmission risk but no yellow fever virus in sampled mosquitoes.

PGC-1α Links Estrogen Receptor Signaling to Japanese Encephalitis Virus Replication in Neuronal cell

This study shows estrogen enhances Japanese Encephalitis Virus replication in neuronal cells via the ER-PGC-1 axis and identifies it as a potential target for sex-specific therapies.

The mitochondrial transaminase GOT2 supports Japanese encephalitis virus replication in neuronal cells

This study identifies the mitochondrial transaminase GOT2 as a metabolic dependency of JEV and a potential host-directed antiviral target through integrated transcriptomics and proteomics analyses.

Novel conserved RNA structural motifs regulate genome cyclization of yellow fever virus

This study identifies a conserved RNA tertiary motif in yellow fever virus that regulates genome cyclization through interactions with the 3'-small hairpin.

First nationwide mosquito surveillance in Northern Irish wetlands reveals presence of Culex pipiens/molestus hybrids

This study surveys mosquito populations in Northern Irish wetlands, identifying Culex pipiens/molestus hybrids and environmental factors influencing vector abundance.

Encephalitic alphavirus infection reduces neurite outgrowth and downregulates Rho GTPase pathways in human iPSC-derived neurospheres

Oviposition and vertical dispersal of Aedes species Meigen 1818 (Diptera: Culicidae) at different heights and seasonal periods in an urban forest fragment in Manaus, Amazonas, Brazil

This study evaluates oviposition and vertical dispersal of Aedes mosquitoes at different heights and seasonal periods in an urban forest fragment, finding higher egg abundance at lower heights and climatic influences on egg density.

A High-Content Pseudotime Framework for Morphological Profiling of Dengue Virus Inhibitors from a Drug-Repurposing Library

This study identifies four DENV inhibitors from a drug library using high-content screening and a pseudotime model to map drug mechanisms onto viral life cycle stages.

Impact of temperature on patient-derived dengue virus breakthrough infections in wMel-infected Aedes aegypti.

This study shows elevated rearing temperatures increase DENV breakthrough infections in wMel-infected Ae. aegypti, reducing wMel density and increasing DENV replication.

MXRA8-dependent chikungunya virus infection in PDGFRα+ mesenchymal cells increases vascular permeability and facilitates hematogenous spread

This study shows that MXRA8-dependent infection of PDGFRα+ mesenchymal cells by CHIKV increases vascular permeability, enabling hematogenous spread and joint swelling.

The effect of ULV-based mosquito control on target and non-target organisms in Hungary: an experimental field study

This study evaluates the short-term impact of ULV insecticide spraying on mosquito and non-target insect populations in Hungary using a BACI design, finding significant reductions in both but highlighting ecological trade-offs.

Tracking two decades of global dengue virus lineage dynamics

This study tracks DENV lineage dynamics over two decades using 37,828 genomes, revealing regional diversity patterns and the impact of COVID-19 on lineage persistence and spread.

Association between breeding-habitat bacterial communities and oviposition behavior of Aedes aegypti: Insights from arboviral outbreak-affected areas of Pune, Western India

The paper investigates bacterial communities in Ae. aegypti breeding habitats and their role in oviposition behavior during arboviral outbreaks in Pune, India.

Mosquito population dynamics are shaped by interactions among larval density, temperature, and relative humidity

The paper investigates how larval density, temperature, and relative humidity interact to shape mosquito population dynamics and traits in a semi-field experiment.

Phylodynamic analysis reveals asymmetric and accelerating global spread of dengue virus

This study uses phylogeographic and phylodynamic methods to analyze DENV genome data, revealing asymmetric global spread patterns and the role of travel over climate in DENV transmission.

Chikungunya Virus Infection of Monocytes Generates a Persistent Macrophage Reservoir That Promotes IFN-π/IL-27-STAT1- and NF-κB-Driven Chronic Arthritis

This study shows CHIKV infection transforms monocytes into persistently infected macrophages that drive chronic arthritis through IFN-π/IL-27-STAT1 and NF-κB pathways.

Long-Term Surveillance Reveals Establishment of Aedes albopictus in Eastern Nebraska, USA

This study reports the establishment of Ae. albopictus in eastern Nebraska through long-term surveillance, showing increasing populations and evidence of overwintering.

EIDD-3525 is a broad-spectrum antiviral against alphavirus infection that targets the nsP4 RNA-dependent RNA polymerase

This study identifies EIDD-3525 as a broad-spectrum antiviral against alphaviruses that inhibits RNA replication by targeting the nsP4 polymerase.

Dengue virus 2 lacking N153 glycosylation displayed enhanced recognition by neutralizing antibodies

The paper shows a dengue virus mutant lacking N153 glycosylation is more susceptible to neutralizing antibodies, as evidenced by increased Fab occupancy and slower dissociation rates.