Developmental Biology and Gene Regulation

The paper uses live imaging to show PRICKLE1 controls neural tube morphogenesis through actomyosin-driven processes independent of planar cell polarity.

This study identifies Rapgef1b's role in regulating Wnt/β-catenin signaling, affecting early embryonic tissue patterning, morphogenesis, and mitotic fidelity in zebrafish.

This study shows that cell division during Xenopus gastrulation affects A-P patterning and neural plate elongation but not neurulation or dorsal mesoderm formation.

The paper identifies Notch signaling as critical for specifying the interstitial lineage in fetal mouse ovaries through single-nucleus transcriptomics and lineage tracing.

This paper shows that the AGEF-1/ARF-1/AP-1 trafficking pathway promotes LIN-12/Notch signaling in the somatic gonad and inhibits it in vulval precursor cells, regulating vulval development in C. elegans.

The paper introduces a framework to analyze positional information in dynamic tissues and applies it to study cell mixing and pattern formation in developing embryos.

The paper shows that BMP signaling is downstream of ERK1/2 in Spiralia and is involved in dorsoventral development, but this hierarchy is lost in annelids with autonomous development.

The paper investigates how cluster assembly dynamics contribute to planar cell polarity polarization by analyzing protein monomer counts in live animals and using mathematical modeling.

The paper develops a toolkit of membrane-localising tags tested across ten animal species to identify effective signals for targeting proteins to the plasma membrane.

This study examines the functional divergence of vertebrate DSCAM paralogs through evolutionary pressures, revealing distinct selective constraints and positive selection patterns in their intracellular domains.

The paper uses single-cell RNA-sequencing to compare neuronal subtypes across species, finding that while core transcriptional features are shared, subtype-defining genes show significant divergence.

The paper shows that cortical flow reinforces PAR polarity against CDC-42 perturbations in C. elegans embryos, with different robustness across developmental contexts.

The paper identifies key regulatory elements in bat limb development by comparing bat and mouse genomic datasets and swapping enhancer sequences to observe phenotypic changes.

The paper shows that 3D epithelial cell geometry and topology influence Notch-Delta signalling range, affecting cell fate patterning in Drosophila wing margins.

The paper shows glia suppress ERK activity in the lateral neuroepithelium to direct the formation of distinct visual processing centres in Drosophila.

The paper shows how three signaling pathways coordinate to establish distinct cell fates along the oral-aboral axis in the developing zebrafish jaw.

The paper uses human iPSC-derived 3D trunk-like structures to study mesodermal lineage decisions and identifies TBX6 and FOXC1/2 as key regulators in human trunk mesoderm diversification.

The paper examines head patterning in a spider, identifying neurosecretory centres and pioneer neurons, providing new insights into arthropod development and evolution.

The paper identifies sim1a as a candidate gene for strabismus using transcriptomic analysis and CRISPR/Cas9 mutagenesis in zebrafish.

This study shows that Lgl removes the Par complex from the membrane at mitotic exit in Drosophila neural stem cells, enabling proper asymmetric division by resetting polarity.

The paper shows how Drosophila male germline stem cells maintain potency through inherited mRNAs and niche signals that define distinct identities.

The paper shows that phenotypic evolution in cichlid fishes can occur through changes in initial developmental conditions rather than modifications to the developmental process itself.

The paper integrates single-cell, spatial, and clonal data to study cranial placode development and evolution, revealing continuous transcriptional landscapes and shared progenitors between placodes.

This study identifies LZTS2 as a regulator of craniofacial development and shows its functional interaction with DYRK1A in Xenopus laevis, with implications for human developmental disorders.

This study identifies Evi1 as a critical mediator between Nodal and Delta-Notch signaling in sea urchin mesoderm development, showing its role in activating Notch135 and mesodermal differentiation.

This paper reviews the evolution of germ cell specification in Panarthropoda by analyzing historical data and proposing new hypotheses about its developmental trajectory.

The paper shows that SMAD6 inhibits BMP/TGF-β signaling, reducing midbrain size in chick embryos by decreasing cell proliferation and affecting axon trajectories.

This study investigates Notch signaling's role in post-embryonic neurogenesis in Platynereis dumerilii, showing its regulation of progenitor specification, differentiation, and neurogenic balance during regeneration and elongation.

The paper uses genomic mosaicism to study clonal dynamics of trunk neural crest-derived ganglia, finding conserved developmental patterns across species.