Hearing, Cochlea, Tinnitus, Genetics

This paper develops a neural model to simulate binaural signal integration with an adaptation mechanism, showing it extends the perceptual range of auditory space and improves localization precision.

This study shows that SIRT3 is not required for hearing recovery after noise exposure in mice, suggesting alternative mechanisms for cochlear homeostasis.

The paper identifies and characterizes four lncRNAs in the mouse cochlea, showing their expression patterns and potential roles in inner ear function.

This study shows chloroquine reduces hair cells in zebrafish and mouse cochlear cultures, suggesting ototoxicity risks.

The paper identifies an in-frame deletion in RIPOR2 as a frequent and highly penetrant cause of adult-onset hearing loss, with implications for genetic therapy.

The paper studies a VGLUT3 variant causing DFNA25 deafness, showing fused stereocilia bundles and elongated synaptic ribbons in a mouse model.

The paper shows that 30% of inner hair cells in the rodent cochlea form electrochemical mini-syncytia through membrane fusion, enhancing sound encoding sensitivity and reliability.

The paper identifies four novel pathogenic variants in COCH causing autosomal recessive nonsyndromic hearing loss and shows non-truncating variants affect RNA-splicing.

The paper uses TRAPseq to identify FGF20-regulated genes in mouse organ of Corti progenitors, finding genes involved in hair cell differentiation and hearing loss.

This paper develops an interleaved stimulus design and open-source software to optimize auditory brainstem response acquisition by reducing adaptation effects and acquisition time.

The paper shows that the MOC reflex enhances speech understanding by gating auditory signals in degraded or noisy environments, with different brain regions engaged depending on the type of speech challenge.

The paper shows that simulated hearing loss in Mongolian gerbils leads to improved sensitivity at the notched frequency but not outside, and behavioral signs of phantom sounds.

This paper introduces a backward encoding model to reconstruct auditory brainstem responses from electrophysiological data, showing high correlation between predicted and measured ABRs.

The paper investigates age-related changes in auditory ribbon synapses of mice, finding increased synaptic transmission and potential compensation for synapse loss.

This study shows that LBH is essential for maintaining cochlear hair cells and stereocilia bundles, with its loss causing progressive hearing loss and OHC degeneration.

This study investigates the recovery of cochlear vibrations after reducing the endocochlear potential, finding that amplification requires both active electromotility and physical shifts in operating conditions.

This study identifies key transcription factors involved in maintaining auditory function in Drosophila and shows their role in age-related hearing loss.

The paper was withdrawn due to lack of full author consent and will not be cited as reference.

The paper develops a flexible mechanical model of the organ of Corti to study how vibrations are transmitted from the basilar membrane to inner hair cells, highlighting cooperative interactions that enhance frequency selectivity and signal amplification.

This study investigates how noise trauma and high-frequency stimulation affect sensory gating in the thalamic medial geniculate body of rodents, finding that HFS reduces evoked potential amplitudes in noise-exposed animals.

This paper identifies a noncoding 10bp deletion in Hgf in mice that causes hearing loss by disrupting neural crest migration into the stria vascularis and reducing the endocochlear potential, mirroring human DFNB39 deafness.

The paper introduces a novel stimulus paradigm to simultaneously record monaural and binaural frequency following responses to identify the binaural interaction component.

The paper investigates noise-induced hearing loss in locust ears, finding that primary auditory neurons' reduced sound encoding ability is likely due to supporting cell pathologies.

The paper investigates noise invariance in inferior colliculus neurons under different noisy conditions and finds that non-stationary noise uniquely affects neural activity, while white and natural stationary noises produce variable responses.

The paper introduces a method for uniform drug delivery across the entire cochlea without disrupting its boundaries, overcoming concentration gradient issues.

This study shows that mechanotransduction activity contributes to cadmium-induced hair cell death in zebrafish lateral line cells.

This study investigates the impact of maternal licking and grooming on auditory development and brain gene expression in Wistar rat pups, finding no effect on hearing onset timing but revealing insights into auditory periphery development and gene regulation.

This study shows that radixin is essential for cochlear amplification by modulating stereocilia function and sound-evoked electrical potentials in guinea pigs.

The paper characterizes adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq in mice and validates findings in humans, identifying potential mechanisms for cochlear regeneration.

This study shows that IC neurons in mice are modulated by locomotion even without sound, and sound-evoked activity is attenuated during movement, increasing frequency selectivity.