Tobias Moser

This paper demonstrates that multichannel optical cochlear implants (oCIs) with ChReef enable improved spectral resolution compared to electrical stimulation in gerbils.

This paper develops an in silico framework to model optogenetic hearing restoration and finds that improved spectral selectivity compensates for lower temporal fidelity in optogenetic stimulation.

This study evaluates the use of fast-closing Chrimson for optogenetic cochlear stimulation, showing improved energy efficiency and temporal fidelity compared to other ChR variants.

The paper reconstitutes synthetic ribbon-type active zones in HEK293 cells using Bassoon, RIBEYE, and CaV1.3 channels, showing structural and functional similarities to native ribbons.

CochleaNet is a deep learning framework for analyzing cochlea imaging data, enabling segmentation and analysis of cochlear structures and gene therapy products.

This paper introduces a high-speed light sheet microscope with isotropic sub-micron resolution for cleared tissue imaging, achieving 850 nm resolution across 1 cm3 samples.

This study uses MINFLUX nanoscopy to map the nanoscale organization of proteins at inner hair cell synapses in mice, revealing nanocluster-based structures in active zones and postsynaptic densities.

This study investigates the role of RTN4RL2 in cochlear synapse formation and function, finding that its deletion leads to synaptic abnormalities and hearing impairment in mice.

The paper investigates the structure and function of otoferlin, showing how it binds Ca2+ and facilitates synaptic vesicle fusion in inner hair cells.

SynapseNet automatically segments synapses in electron micrographs using deep learning, enabling efficient analysis of synaptic structures.

This paper introduces ChReef, an improved optogenetic tool with enhanced performance in sensory and cardiac systems, demonstrating its effectiveness in restoring visual and auditory function.

This paper develops a low-weight, wireless optogenetic cochlear implant system for hearing restoration in deafened rats, demonstrating its ability to enable locomotion tasks in response to acoustic stimulation.

The paper characterizes CryoRhodopsins from cold environments, revealing their dual functionality and structural adaptations to low temperatures.

This study shows that variations in Ca2+ channel activation in inner hair cells affect spiral ganglion neuron firing rates and sound threshold, with implications for noise-induced hearing loss in patients with the CaV1.3A749G mutation.

The paper shows that combinatorial Maf transcription factors establish subtype-specific synaptic properties in spiral ganglion neurons.

This study improves optogenetic modification of spiral ganglion neurons in gerbils using microcatheter-based AAV delivery, achieving reliable ChR expression in 80% of treated animals but with limited transduction efficiency.

The paper investigates neuromodulation of the endbulb of Held synapse in the cochlear nucleus, finding that norepinephrine increases miniature excitatory postsynaptic currents while serotonin and evoked transmission are unaffected.

This study determines the cryo-EM structures of human myoferlin and dysferlin bound to Ca2+ and lipids, revealing how their domain dynamics enable membrane binding and fusion.

This study investigates how synaptic heterogeneity in inner hair cells contributes to the diversity of spiral ganglion neuron firing by analyzing ex vivo IHC-SGN synapse recordings.

The paper uses iGluSnFR to measure glutamate release and assess short-term synaptic plasticity at the endbulb of Held synapse in mouse spiral ganglion neurons.

This paper develops a framework for optogenetic control of the auditory pathway by optimizing light pulse parameters to enhance spike probability and information encoding in spiral ganglion neurons.

This study uses optogenetics and electron tomography to analyze the ultrastructure of cochlear inner hair cell ribbon synapses during stimulation, showing increased docked synaptic vesicles and no evidence of homotypic fusion.

This study investigates the role of piccolino in cochlear inner hair cell synapses, finding it contributes to active zone organization and is essential for normal synaptic transmission.

The paper develops fast photoswitchable ligands for controlling neuronal activity in the cochlea, enabling rapid and sustained photocontrol without genetic modification.

This study shows that TMEM16A in Kollikers organ controls Ca2+ waves and is essential for auditory brainstem network refinement and frequency-selectivity.

This paper investigates the role of RIM-BP2 in organizing Ca2+ channel topography and regulating synaptic vesicle release probability and replenishment at a fast central synapse.

The paper uses MINFLUX nanoscopy to visualize the molecular architecture of the photoreceptor active zone, revealing a serially duplicated complex of bassoon-RIM2-ubMunc13-2-CAST.

The paper reconstructs neural circuitry in the mouse cochlea using electron microscopy, showing differences in efferent innervation of spiral ganglion neurons based on their synaptic connectivity with inner hair cells.

The paper investigates how sensory cells encode sound intensity by varying Ca2+ influx-release coupling among presynaptic active zones.

The paper shows that 30% of inner hair cells in the rodent cochlea form electrochemical mini-syncytia through membrane fusion, enhancing sound encoding sensitivity and reliability.