Hearing, Cochlea, Tinnitus, Genetics

This study uses a CX3CR1 fate-mapping model to show that cochlear macrophages are heterogeneous in origin, distribution, and fate after acoustic trauma.

This paper develops a spiking neural network model of human auditory brainstem nuclei to study sound localization mechanisms using ITDs and ILDs.

The paper identifies ybx1 as a key regulator promoting rapid hair cell regeneration in zebrafish lateral-line neuromasts by upregulating atoh1a, using the DELAY algorithm to infer gene regulatory networks.

The paper investigates the distribution of metabotropic serotonergic receptors in GABAergic and glutamatergic neurons of the auditory midbrain and finds differential receptor expression patterns.

The paper reveals how male mosquitoes generate audible distortion tones from inaudible high-frequency sounds to detect female flight tones in noisy environments.

The paper identifies gene expression changes in the vestibular sensory epithelium during chronic ototoxicity, finding early downregulation of HC-specific genes and upregulation of stress mediators across species and compounds.

This study uses live-cell single-molecule fluorescence microscopy to investigate MYO7A trafficking in stereocilia, revealing its dimeric form and movement restrictions mediated by plasma membrane and F-actin interactions.

This study shows that Jagged1/Notch signaling maintains cochlear supporting cell progenitor-like characteristics and metabolic genes, and its inhibition enhances hair cell regeneration.

This study investigates the role of RIMBP2 in murine cochlear hair cells, finding it essential for OHC survival and critical for IHC exocytosis.

The paper investigates changes in auditory steady-state response (ASSR) in tinnitus patients and finds no significant amplitude differences between acute and chronic tinnitus but notes reduced amplitude in tinnitus groups compared to controls.

This study identifies a KPNA7 mutation causing otosclerosis by disrupting PTHrP nuclear transport and reactivating chondrogenesis in the otic capsule.

This study shows that enhancing medial olivocochlear feedback protects against early noise-induced hearing damage in mice, with long-term auditory benefits.

This study investigates the developmental plasticity of cochlear inner hair cell ribbon synapses using live-cell imaging, revealing activity-dependent mechanisms in their structural maturation.

This study shows prdm1a drives a fate switch between zebrafish lateral line and ear hair cells, altering morphology and transcriptome.

The paper investigates how perceptual novelty contributes to tinnitus persistence by analyzing P300 responses in acute, post-acute, chronic tinnitus, and control groups.

This study shows KCNQ4 deficiency causes cochlear dysfunction by disrupting protein localization, OHC organization, and cell survival, with noise not worsening hair cell damage in the model.

The paper models outer hair cells as coupled oscillators to show how they overcome impedance mismatch and amplify basilar membrane motion, supporting the cochlea's high-frequency performance.

The paper investigates tinnitus onset by analyzing IDAEP slopes, finding increased sensory reactivity during acute tinnitus that decreases over time.

This study examines age-related changes in fusiform cells of the dorsal cochlear nucleus in mice, finding stable physiology post-weaning but altered firing properties and dendritic complexity during ARHL onset.

This study identifies Paralemmin-3 as a critical protein for maintaining the structural integrity of the lateral wall in auditory hair cells, with its loss causing hearing impairment and structural collapse.

The paper investigates how inferior colliculus neurons in awake mice respond to notched noises, showing suppression during stimulation and enhancement after, with implications for auditory enhancement and Zwicker tone mechanisms.

This study shows that CASZ1 regulates outer hair cell maturation and is essential for hearing by controlling gene expression and F-actin density.

The paper assesses sex differences in auditory brainstem responses (ABRs) and morphological features in hispid pocket mice, finding significant sex differences in hearing thresholds but not in amplitudes, latencies, or craniofacial dimensions.

This study uses whole-genome sequencing and functional assays to improve genetic diagnosis of sensorineural hearing loss, achieving a 55.6% diagnostic yield through comprehensive genomic profiling.

This study investigates cognitive difficulties in tinnitus patients and finds reduced arousal system function, with no specific executive dysfunction linked to tinnitus.

This study investigates how different subject instructions affect the quality of auditory representation characterization using reverse correlation, finding that detecting a hidden signal in stimuli yields the best reconstruction.

This study investigates how mutations in prestin affect cochlear amplification and hearing, finding that reduced prestin function leads to frequency-specific hearing loss but not complete deafness.

This study shows that variations in Ca2+ channel activation in inner hair cells affect spiral ganglion neuron firing rates and sound threshold, with implications for noise-induced hearing loss in patients with the CaV1.3A749G mutation.

The paper investigates low-frequency sound percepts (LFSPs) by comparing hearing thresholds and spontaneous otoacoustic emissions in individuals with and without LFSPs, suggesting subjective tinnitus as a likely cause.