Hearing, Cochlea, Tinnitus, Genetics

This study shows chloride binding does not affect very high-frequency nonlinear capacitance in mouse outer hair cells, suggesting mechanical loads, not anion interactions, govern high-frequency prestin function.

This paper estimates cochlear frequency selectivity using a convolution model of forward-masked compound action potentials in chinchillas, showing close agreement with auditory nerve tuning curves.

This study examines cadherin localization during postnatal cochlear development and finds that F-actin remodeling and changes in cell adhesion drive fluid-filled space formation in the organ of Corti.

This study shows that EBF1 is crucial for inner ear development, regulating cochlear structure and cell numbers, and is necessary for normal hearing function.

This study measures hearing ability in prairie voles, finding sex-specific differences in monaural hearing but not binaural hearing or morphology.

This study applies reverse correlation to reconstruct non-tonal tinnitus percepts in patients, showing higher response prediction accuracy than chance.

This study measures subcortical responses to continuous speech in sound-field conditions and finds that 16 minutes of data is sufficient to reliably estimate TRFs with clear wave V peaks.

This study shows that zebrafish lateral line hair cells use anion efflux, not cation influx, for mechanotransduction due to low external cation concentrations.

This study shows that Kremen1 inhibits Wnt signaling and hair cell formation in zebrafish lateral line, and its absence leads to excessive regeneration through increased support cells when Wnt is overactivated.

This study examines how age and noise exposure affect tympanal displacement in desert locusts, finding age-related stiffness increases and temporary noise-induced displacement changes.

The paper uses optogenetics to study the role of supporting cells in force transmission to and from outer hair cells in the mouse cochlea, finding that hyperpolarizing these cells suppresses cochlear amplification and alters mechanical responses.

The paper develops an auditory model with efferent gain control that simulates increased firing rates in inferior colliculus neurons in response to amplitude-modulated noise.

The paper analyzes the cochlear transcriptome of an outbred mouse population to identify cell-type specific changes associated with age-related hearing loss.

This study shows that SRF and MRTFB differentially regulate actin cytoskeleton in hair cells, with SRF-CNN2 playing a critical role in stereocilia and cuticular plate structure.

The paper identifies transcriptional and epigenetic programs driving hair cell differentiation from supporting cells in cochlear organoids and predicts novel regulatory factors.

The paper presents a complete computer model of the peripheral auditory system integrating all components to study hearing mechanisms and deafness.

The paper investigates eye-movement-related eardrum oscillations (EMREOs) in individuals with normal hearing, identifying consistent and variable features of these responses.

This study investigates how noise-induced tinnitus affects auditory gating in mice and whether cannabis extract and nicotine can improve auditory pre-attentional processing.

The study investigates acoustic sensitivity of zebrafish otolithic endorgans, finding higher noise-induced hair cell loss and synaptopathy in saccule and lagena compared to utricle.

The paper shows that glucose metabolism and morphogen signaling interact to establish tonotopic identity in developing hair cells by altering metabolic gradients and morphogen signaling.

The paper assesses supporting-cell survival in human cochleas and finds it correlates with audiogram slope and ototoxic hearing loss.

This study identifies the distinct roles of GNAI proteins in mouse auditory hair cell polarization and morphogenesis, revealing compensatory mechanisms and novel defects upon their inactivation.

This study shows TRPA1 activation in cochlear supporting cells leads to prolonged Ca2+ responses and contractions that affect cochlear sensitivity after acoustic trauma.

The paper examines branching patterns of layer 5 and 6 auditory corticofugal axons in mice, finding they have complementary distributions and extensive branching.

This paper develops and validates a web-based platform for psychoacoustic experiments, showing agreement with lab-based results on multiple tasks.

This study identifies ZBTB20 as essential for cochlear maturation and hearing in mice by regulating terminal differentiation of non-sensory epithelial cells.

This study compares single-cell transcriptomic profiles of human inner ear organoids with fetal and adult inner ear tissues to assess their ability to model inner ear disorders.