Liver Disease and Transplantation

Cirrhosis-associated immune dysfunction reflects impaired intestinal CD8ab⁺ intraepithelial lymphocyte compartmentalization

The paper investigates immune dysfunction in cirrhosis by analyzing CD8ab⁺ intraepithelial lymphocytes and identifies CCL25-CCR9 axis disruption as a key factor.

Humoral Immune Dysregulation Defines High-Risk Cirrhotic Ascites

The paper analyzes human ascites fluid to identify immune dysregulation features associated with poor outcomes in cirrhosis, finding that B cell dysfunction, not microbial translocation, defines high-risk cases.

Early Identification of At-Risk Patients: ProteomicSignature Predicts Progression to DecompensatedCirrhosis

This paper identifies a four-protein proteomic signature that predicts progression to decompensated cirrhosis with high accuracy in both training and external validation cohorts.

Non-selective beta blockers reduce bystander CD8+ T cell activation in decompensated liver cirrhosis

This study shows that non-selective beta blockers reduce bystander CD8+ T cell activation in decompensated liver cirrhosis without affecting antigen-specific responses.

Immunological characterization of peritoneal exudate cells in liver cirrhosis patients

This study characterizes peritoneal exudate cells in liver cirrhosis patients using single-cell and bulk RNA sequencing, revealing shifts in immune cell populations and gene expression with disease severity.

Increased versican and fibrosis in mesenteric lymph nodes disrupts immune surveillance and drives systemic bacterial dissemination in cirrhosis

This study identifies increased versican and fibrosis in mesenteric lymph nodes as drivers of immune suppression and systemic bacterial dissemination in cirrhosis, with plasma versican levels serving as a prognostic biomarker for sepsis-related mortality.

Predicting the Impact of Dialyzer Choice and Binder Dialysate Flow Rate on Bilirubin Removal

The paper develops a computational model to predict bilirubin removal in binder dialysis systems and finds it is independent of dialysate flow rate within clinical ranges.

Top-Down Proteomics Identifies Plasma Proteoform Signatures of Liver Cirrhosis Progression

This study uses top-down proteomics to identify plasma proteoform signatures that distinguish stages of liver cirrhosis progression.

Aberrant remodelling of astrocytic architecture in acute hepatic encephalopathy: complexity of oedematic atrophic astrocytes

This study investigates morphological changes in astrocytes during acute hepatic encephalopathy, finding hypertrophy of primary branches and atrophy of terminal leaflets linked to decreased expression of AQP4, phosphorylated ezrin, and profilin-1.

FOXA2 is essential for maintaining the urea cycle in acute liver failure

This study identifies FOXA2's role in maintaining urea cycle function in acute liver failure by regulating CPS1 transcription and preventing hyperammonemia.

Enhanced meningeal lymphatic drainage ameliorates neuroinflammation and hepatic encephalopathy in cirrhotic rats

This study shows that enhancing meningeal lymphatic drainage reduces neuroinflammation and improves motor function in cirrhotic rats with hepatic encephalopathy.