Chen Shao

This study identifies TGF-β as a key regulator of liver progenitor cell quiescence and activation, showing its dual role in inhibiting proliferation while being counteracted by HGF and EGF signals.

This study identifies super-enhancers as critical regulators of liver function genes in hepatocytes and liver progenitor cells during health and acute liver failure.

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

This study shows retinoic acid secreted by activated hepatic stellate cells promotes liver progenitor cell activation in acute liver failure, improving patient outcomes.

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

This study identifies FOXA2's role in maintaining urea cycle function in acute liver failure by regulating CPS1 transcription and preventing hyperammonemia.