Oliver T. Burton

The paper investigates immune dysfunction in cirrhosis by analyzing CD8ab⁺ intraepithelial lymphocytes and identifies CCL25-CCR9 axis disruption as a key factor.

AutoSpectral enhances spectral flow cytometry accuracy by optimizing unmixing matrices and matching autofluorescence at the cellular level, significantly reducing errors in complex datasets.

The paper uses probabilistic modeling on a parabiosis dataset to analyze lymphocyte migration kinetics and dwell times across tissues, revealing cell type- and tissue-specific residency patterns.

This paper designs IL2 muteins with enhanced Treg or CD8 T cell specificity and improved production by predicting mutations using SolubiS and testing their functional and structural properties.

The paper analyzes tissue-resident regulatory T cells (Tregs) in non-lymphoid organs, showing they share phenotypes, transient residency, and TCR sequences, with tissue-agnostic re-entry capabilities.

AutoSpill calculates spillover coefficients for high-parameter flow cytometry data using automated gating and iterative refinement, improving compensation without requiring manual tuning or well-defined controls.

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.