Stefan Munker

The paper trains a machine-learning model on native protein structures to predict interaction preferences and energetics without using affinity or mutation labels, achieving performance comparable to existing methods on a benchmark.

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

This study identifies super-enhancers as critical regulators of liver function genes in hepatocytes and liver progenitor cells during health and acute liver failure.

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

This study shows retinoic acid secreted by activated hepatic stellate cells promotes liver progenitor cell activation in acute liver failure, improving patient outcomes.

This study identifies FOXA2's role in maintaining urea cycle function in acute liver failure by regulating CPS1 transcription and preventing hyperammonemia.