Circadian rhythm and melatonin

The paper identifies circadian gene expression patterns in mouse renal proximal tubules and provides a web resource for these data.

This study shows that mouse dentate granule neurons exhibit a 24-hour excitability oscillation regulated by G-protein signaling and Bmal1, affecting memory and spatial discrimination.

This paper uses in vivo calcium imaging and electrophysiology to show AVP neurons in the SCN exhibit unstable single-cell rhythms but coherent network activity with a strong circadian rhythm.

This study identifies novel regulators of Nutritional Compensation in the circadian clock of Neurospora crassa and shows conservation in mammalian cells.

This study identifies age-dependent and tissue-specific changes in the circadian transcriptome of male mice, showing reduced rhythmic gene expression and increased variability in aged tissues.

The paper identifies three distinct circadian phases in Drosophila pacemaker networks and shows how they drive rhythmic activity in downstream neurons.

This study shows that sleep deprivation alters the mouse lung transcriptome, suppressing immune systems and activating SARS-CoV-2 replication genes, increasing viral infection risk.

This study shows that mating in Drosophila females disrupts their ability to anticipate the night-day transition, mediated by sex peptide acting on PPK+ neurons and affecting PDF levels.

This study identifies a genetic variant associated with light sensitivity by analyzing the interaction between daylight exposure and chronotype in a large cohort.

The paper identifies age-dependent changes in diurnal transcriptome rhythms in Drosophila using a novel Fourier-based method, revealing shifts in core clock and pathway rhythmicity.

The paper identifies a small molecule, M47, that destabilizes CRY1 and extends lifespan in p53 knockout mice by enhancing apoptosis and reducing CRY1 levels.

Tempo is a Bayesian method for inferring circadian phase from scRNA-seq data, providing accurate estimates and uncertainty quantification.

This paper introduces LTM, an in silico method to identify genetic influences on circadian clock function using gene expression data, and finds the cell cycle and extracellular matrix pathways are strongly associated with clock strength in human tissues.

This study identifies the role of thalamic GABAergic neurons in circadian responses to light, showing their involvement in vigilance state transitions and dim light entrainment.

The paper develops a method to measure circadian clocks in live Drosophila and shows that peripheral clocks can oscillate independently of the brain clock.

This study shows that knocking out core circadian clock genes in silkworms disrupts photoperiodic diapause induction during both embryonic and larval stages.

This study examines the impact of Mendelian sleep and circadian genetic variants in population cohorts and finds no strong associations with extreme sleep traits, though some variants show minor effects.

This paper identifies L-Cryptochrome as a moonlight interpreter that distinguishes between sun- and moonlight to regulate monthly oscillator entrainment in Platynereis dumerilii.

SleepMat is a new software program that provides a broader range of circadian and sleep parameter analyses for Drosophila data.

This study investigates whether high-melanopic light affects sleep and vigilance, finding no differential effects despite melatonin suppression.

This study investigates the sex-specific role of NPAS2 in fentanyl-induced analgesia, tolerance, hyperalgesia, and dependence using NPAS2-deficient mice.

The paper identifies dopamine and GPCR-mediated modulation in Drosophila clock neurons that regulate sleep timing.

This study shows that glial cells regulate sphingolipid levels to drive daily remodeling of circadian circuits in Drosophila.

The paper develops a data-driven model of the circadian clock in Neurospora crassa using luciferase reporter data to estimate parameters and reveal the role of FRQ maturation in circadian rhythms.

This study analyzes the circadian nuclear and cytoplasmic transcriptomes in mouse liver to understand temporal regulation of RNA processing and stability.

This study examines how fentanyl affects sleep architecture and how the circadian factor NPAS2 influences these changes during withdrawal in male mice.

The paper analyzes a baboon diurnal transcriptome atlas to show that 53.4% of genes are rhythmically expressed and that circadian gene networks exhibit daytime and nighttime modes with distinct biological functions.

The paper introduces the PAICE suite to detect circadian oscillations in RNA and protein data, revealing post-transcriptional regulation and spliceosome timing in mouse macrophages.

The paper investigates whether light affects human prefrontal cortex activity through a pathway similar to that in animals, finding luminance-dependent signals in multiple brain regions.

This study uses microendoscopic Ca2+ imaging to show that SCN neurons in vivo exhibit both fast Ca2+ spikes and slow baseline changes, revealing diverse activity patterns within a coordinated circadian network.