Amit Singh

This study uses an agent-based model to show that aging disrupts mechanoregulation of bone adaptation in mice, leading to altered bone formation and resorption dynamics.

Spatial μProBe integrates multimodal imaging to analyze spatial gene expression and mechanical environments in musculoskeletal tissues.

The paper develops a 3D bioprinted bone model from patient-derived cells to study donor-specific therapeutic responses to DKK1Ab in osteogenesis imperfecta.

This study uses spatial transcriptomics to analyze gene expression in relation to mechanical strain in fracture healing, identifying strain-dependent gene expression patterns.

This study characterizes frailty in PolgA mice, showing sex-specific differences and parallels to human aging.

This study examines daily metabolic and locomotor rhythms in prematurely ageing PolgA mice, finding sex-specific differences in activity and metabolic patterns.

This study identifies an endogenous NCAM1-14.3.3.ζδ-derived peptide interaction that promotes angiogenesis and osteogenesis, offering a therapeutic target for age-related bone diseases.

The paper develops a data-driven model of the circadian clock in Neurospora crassa using luciferase reporter data to estimate parameters and reveal the role of FRQ maturation in circadian rhythms.

This study annotates the full-length transcripts of Chaetomium thermophilum using deep RNA sequencing, identifying novel genes and improving existing annotations.