Reproductive Biology and Fertility

This study shows that P1P enhances porcine oocyte maturation and embryo development by reducing oxidative stress and apoptosis.

This study shows that human oocytes with DNA damage can complete meiosis-I and extrude the first polar body, unlike mouse oocytes which arrest due to SAC signalling.

This study shows that NAD+ repletion with NMN improves oocyte quality and fertility in aged animals, and enhances IVF success in older mice.

This study shows that retinoic acid receptors are not required for meiosis initiation in mouse fetal ovaries, challenging the current model and suggesting a role for CYP26B1 in meiosis prevention.

This study shows maternal obesity increases chromosome abnormalities in oocytes, likely due to weakened sister-chromatid cohesion, and this effect is more pronounced in older mice.

The paper shows that inhibiting L1 reverse transcriptase and the Chk2 checkpoint prevents fetal oocyte attrition, preserving the ovarian reserve.

This study investigates whether mtDNA levels in trophectodermal cells predict blastocyst quality, ploidy, implantation, and clinical outcomes, finding no association but a distinction between aneuploid and euploid blastocysts.

This study shows that CCNB2 is essential for meiotic progression in mouse oocytes, as its absence causes defects in pre-MPF activity, spindle assembly, and meiosis I completion.

This study shows that Mfn1 is essential for oocyte-granulosa cell communication, which regulates oogenesis, while Mfn2 has a lesser role.

This study shows that a personalized superovulation protocol for cynomolgus monkeys increases MII-stage oocyte retrieval and embryo generation via ICSI, leading to successful pregnancies and fetal development.

The paper develops an automated tool for annotating embryo morphokinetic parameters, showing high concordance with manual annotation in human and mouse embryos.

This study shows RNF212 mediates oocyte quality control by impeding DNA break repair during meiosis, ensuring defective eggs are eliminated.

This study shows that bovine blastocyst development depends on threonine catabolism via TDH, with no metabolic difference between ICM and TE cells, unlike in mice.

This study investigates long-term phenotypic effects of vitrified-thawed embryo transfer in rabbits, finding reduced organ weights and molecular changes in liver transcriptomic and proteomic profiles.

This paper develops an AI system to assess human blastocyst quality using deep learning, achieving 98% accuracy and identifying clinical factors affecting pregnancy rates.

The paper identifies 15 new genes involved in egg activation and early embryogenesis in Drosophila by analyzing phospho-regulated maternal proteins through RNAi knockdown.

This study shows that preovulatory aging in mice reduces fertilization rates and causes early genome activation in embryos.

The paper investigates non-random fertilization in mice, showing that certain genes and diets can bias genotype combinations at fertilization, challenging the assumption of random genetic combination.

This study investigates how the location of a trophectoderm biopsy in human blastocysts affects their development, finding that biopsies near the inner cell mass improve blastocoel development.