Reproductive Biology and Fertility

This study shows that codon composition affects mRNA stability and protein abundance in human oocytes, with age-related changes in these associations impacting oocyte quality.

This study identifies Tdrd3 as a regulator of meiosis II in mouse oocytes by controlling Emi2 mRNA translation, ensuring proper MII spindle formation.

This study uses single-cell RNA sequencing to analyze fetal ovary development in monkeys, identifying key cellular processes and gene expression patterns in germ cells.

The paper shows that a small increase in CHEK1 activity causes arrest of the first zygotic division in human embryos, with implications for assisted reproduction.

This paper uses AI and imaging to analyze cytoplasmic movement in early human embryos to predict blastocyst development, showing improved accuracy when combining AI with expert assessment.

The paper identifies mechanical and signaling mechanisms guiding embryo movement and spacing in mice, showing that implantation sites are not random but influenced by embryo number and communication.

The paper identifies a missense variant in HSF2BP linked to POI, showing it impairs meiotic recombination by affecting its interaction with MIDAP and reducing recombinase activity.

The paper analyzes transcriptome and methylome data from mouse oocytes to understand aging and maturation, identifying biomarkers and a predictive model for oocyte quality.

The paper identifies two distinct somatic cell populations in mouse fetal ovaries that support different follicle development stages through single-cell RNA sequencing.

The paper uses single-cell RNA sequencing to analyze female germ cell development in mice, identifying seven clusters and uncovering Dpy30's role in meiosis initiation.

The paper uses single-cell RNA sequencing to show cyclophosphamide induces apoptosis in human ovarian primordial follicles, not follicle growth activation, causing acute ovarian reserve depletion.

This study shows the Hira complex is essential for male pronucleus formation in mice and humans, with Cabin1 and Ubn1 playing critical roles, and demonstrates potential for IVF therapy.

This study confirms a SYCE1 mutation causes infertility in humanized mice, revealing synapsis defects as the molecular mechanism.

This study uses single-cell RNA sequencing to analyze meiosis initiation in mouse ovaries, identifying distinct cell populations and new genes involved in meiotic progression.

This study identifies EXOSC10 as a key regulator of the transcriptome during the growth-to-maturation transition in mouse oocytes, showing its role in RNA degradation and oocyte quality.

This study shows DAZL regulates maternal mRNA translation in oocytes by both repressing and activating specific transcripts during maturation.

The paper examines how different fertilization methods affect preimplantation gene regulation in mouse embryos, identifying stable and flexible gene expression patterns and the role of sperm RNAs in development.

This study shows that ESR2 prevents excessive activation of primordial follicles, and its disruption leads to premature ovarian senescence and reduced AMH and estradiol levels.

This study shows that DUX4 regulates the oocyte-to-embryo transition in humans by activating enhancers and promoting genome reprogramming.

The paper identifies signaling interactions and transcription factors involved in ovarian follicle development using protein interaction networks and public microarray data.

The paper uses RiboTag/RNA-Seq to show a global switch in maternal mRNA translation during oocyte meiotic resumption, with repression of previously active transcripts and activation of previously repressed ones.

This study shows prolonged storage of Drosophila oocytes leads to meiotic spindle instability, similar to human oocyte issues, and identifies Hsp26 and Hsp27 as key factors in age-related decline.

This study shows that BMP15 is essential for porcine ovarian and follicular development, as its knockdown leads to reduced fertility and ovarian dysfunction.

This paper applies extracellular flux analysis to measure mitochondrial function in mammalian oocytes and embryos, showing real-time OCR partitioning and stable efficiency during development.

The paper shows that p38-MAPK regulates blastocyst development in response to amino acid availability and oxidative stress, affecting cell lineage specification and blastocyst size.

The paper establishes that ZP1 mutations cause zona pellucida absence and female infertility in both rats and humans by sequestering ZP3 and ZP4 intracellularly.

This study shows that the DNA damage response, specifically CHK2, regulates oocyte elimination and follicle formation in mammals by controlling meiotic recombination and cyst breakdown.

The paper uses single-cell RNA sequencing to analyze gene expression dynamics in mouse ovarian germ and granulosa cells during primordial follicle assembly, identifying gene clusters, trajectories, and regulatory networks.

The paper integrates multi-omics data to analyze gene expression dynamics in mouse embryos, revealing discrepancies between transcript and protein levels during early development.