Cellular Mechanics and Interactions

The paper shows that myosin cluster dynamics in multi-cellular epithelial wound rings are conserved with single-cell cytokinetic rings and can predict stress generation and shape changes during morphogenesis.

This study uses AFM to analyze the rheological properties of ascidian embryo cells during cleavage stages, revealing power-law behavior and a master curve correlation between modulus and fluidity.

This study shows that viscoelasticity of substrates affects fibroblast adhesion, migration, and YAP activity, suggesting its importance in fibrotic disease modeling.

The paper studies how cell division affects the extracellular matrix in human colonic epithelium organoids using 4D imaging and Digital Volume Correlation.

This study measures intracellular strain using microscopy and finds an inverse relationship between cytoplasmic and nuclear strains controlled by nucleo-cytoskeletal coupling.

This study examines density-dependent migration in Acanthamoeba castellanii, showing that collisions affect motility parameters, with intrinsic speed constant and persistence time and diffusion governed by collisions.

This paper introduces a minimal in vitro assay to study cell intercalation, showing that interfacial tension and migratory forces drive this process in epithelial cells.

This study investigates the mechanics of epithelial buckling by combining experiments and simulations, revealing multiscale wrinkling dynamics and how they can be controlled through curvature and contractility.

This study identifies N-Cadherin and its effectors in regulating tunneling nanotube formation and function in neuronal-like cells.

This paper introduces a biaxial stretcher to estimate single-cell anisotropy, simplifying mechanical testing through image-based displacement measurements without additional sensors.

The paper shows that vimentin absence in glioblastoma cells affects nuclear mechanotransduction, DNA damage response, and cell survival under stress.

The paper shows that patterned junctional contractility coordinates cell behavior in mixed epithelia, leading to spatial order and 3D tissue structure during development.

This study shows Dock8 regulates mechanosensitive actin redistribution in immune cells, maintaining cohesion and protecting the nucleus during migration through confined environments.

This study uses a computational model to show that fluid-like tumor spheroids cause more ECM remodeling than solid-like spheroids due to shape fluctuations and cellular motility.

This study shows that cells can sustain intracellular pressure gradients over minutes, revealing the role of cytoplasmic poroelasticity in mechanical responses and cell physiology.

This study identifies a mechanochemical feedback loop between Wnt signaling and tissue stretching that drives axis formation in Hydra regeneration.

This paper identifies plastins as novel cytoskeletal pH sensors that reduce F-actin bundling at alkaline pH, affecting actin dynamics and potentially contributing to cancer progression.

This paper develops a multiscale theory to model mesenchymal cell migration in 2D viscoelastic channels, showing how substrate stiffness and confinement geometry affect migration speed and direction.

This study reveals that Arpin homodimerization enhances inhibition of Arp2/3 complex-mediated actin polymerization, suppressing cancer cell migration and metastasis.

This paper develops a microfluidic system to study spatial control of endocytosis and adhesion in breast cancer cell migration, finding that front-targeted inhibition enhances migration speed and persistence.

This study shows that osmotic compression relaxes tissue contractility in different cell types, mediated by RhoA and myosin activity, suggesting a feedback mechanism in morphogenesis.

The paper shows that macropinocytosis reduces cell size to alleviate tissue crowding, working alongside cell extrusion.

This study investigates how compressive strain affects astrocyte morphology, metabolism, and ECM modification in a 3D hydrogel model of the optic nerve head.

The paper describes the fabrication of microwells for encapsulating active matter, enabling controlled studies of cytoskeleton dynamics and other cellular processes.

This study uses a 3D microfluidic model to investigate how uremic toxins affect monocyte-endothelial interactions under hypertension and varying matrix stiffness.

This study examines how 3D microenvironment mechanics influence hiPSC-derived endothelial progenitor cell self-assembly and network formation.

This paper uses simulation-based inference to estimate cell-mechanical parameters from 1D cell trajectories, demonstrating its effectiveness in analyzing breast cell lines and drug effects.

This study shows that TWF-2, a twinfilin ortholog in C. elegans, modulates actomyosin contractility in the spermatheca by regulating F-actin levels.

The paper evaluates kinematic relationships in Drosophila wing development using modified texture tensor analysis and validates their compatibility with a hydrodynamic model.

The paper examines how motor activity affects the mechanical properties of actomyosin networks, showing nonmonotonic responses with distinct fluidization and stiffening regimes.