Cellular Mechanics and Interactions

The paper investigates how composite endomembrane suspensions in eukaryotic cells contribute to cytoplasm rheology, finding that ER structures enable viscoelastic properties through yolk flocculation.

This study shows that SEPT7 depletion reduces breast cancer cell invasion in 3D collagen gels by affecting actin-based protrusions and cell shape.

This study shows PAK4 and Afadin cooperate to maintain epithelial integrity by promoting vertex remodeling, with PAK4 inhibition disrupting junctional continuity and barrier function.

This study identifies budesonide as a drug that inhibits stiffness-induced aggressiveness in pancreatic ductal adenocarcinoma by targeting mechanical cues.

This study shows SGEF regulates epithelial morphogenesis by maintaining junction stability, actomyosin organization, and extracellular matrix remodeling during 3D cyst development.

The paper shows N-cadherin is orientationally ordered at low mechanical load cardiomyocyte junctions but disordered at high load, indicating adaptation to local force conditions.

This study shows plant actin networks rapidly respond to mechanical cues, similar to animal cells, and function as mechano-adaptive scaffolds.

This study compares viscoelastic recovery time of chondrocytes from monolayer and alginate cultures, finding significant differences linked to pericellular matrix properties.

This study develops a multiscale cytoskeletal network model to simulate shear rheological properties and their evolutionary mechanisms, revealing how chemo-mechanical coupling and actin filament dynamics influence cellular mechanical responses.

The paper screens compounds to identify mechanical mediators by measuring cell deformability, finding NUDT5 as a key mediator in ovarian cancer.

The paper shows that apical spectrin organizes actin filament bundles in C. elegans to pattern cuticle ridges, and its loss disrupts ridge formation and matrix delamination.

This study shows fibroblasts use two distinct adhesion strengthening modes, slow and fast, in response to fibronectin stiffness, with fast mode dependent on myosin II and signaling hub components.

This study shows that Dachsous-Fat signaling regulates wing shape in Drosophila by modulating tissue tension during larval development, leading to elongated wings.

This study identifies a novel mixing mechanism in giant amoebae using a sol-gel transition strategy, achieving rapid cytoplasmic mixing.

This paper develops a FRET-based tension sensor (mDia1TS) to measure mechanical tension in formin-elongated actin filaments in live cells and quantifies changes in tension under different conditions.

This study shows that Notch signaling and junctional mechanics are coupled during asymmetric division of sensory organ precursors in Drosophila, with Notch shaping junctional tension and vice versa.

This study shows fibroblasts align differently at soft/soft vs. soft/stiff hydrogel interfaces, with increased myofibroblast differentiation at stiff interfaces due to mechanical cues alone.

This study shows that moderate reduction of actomyosin contractility protects epithelial cell-cell contacts from rupture under large external stretch by reducing both active and passive mechanical forces.

This study shows that mechanical strain on intestinal organoids reduces the maturity of absorptive lineage cells by expanding early-stage enterocytes and downregulating maturation programs.

This study shows that integrin-mediated mechanotransduction through supramolecular ligand clustering limits mitochondrial respiratory capacity, thereby suppressing cancer cell motility and tumor growth.

This study shows mechanical tension, not just biochemical signals, actively drives cell extrusion via RhoA-mediated contractility in epithelial monolayers.

This study uses SICM and cell de-roofing to analyze the nanotopography and mechanics of actin stress fibers during contraction in U2OS cells.

This paper introduces a vascular chip that enables controlled experimentation with disease-relevant wall shear stress topology, revealing its effects on endothelial mechanics and function.

This study shows that SPIN90-Arp2/3 complex nucleates unbranched actin filaments in stress fibers, enhancing cell migration by regulating traction and adhesion.

This paper demonstrates that 4D force patterning using a magnetically actuated vessel-on-a-chip platform enables precise spatiotemporal control over angiogenesis by modulating mechanical strain magnitude, frequency, and direction.

The paper develops a finite-element framework to simulate mechanochemical feedback in cell shape and mechanics, revealing new insights into cell migration, neutrophil protrusion, and dendritic spine remodeling.

This study identifies dynein-microtubule forces as essential for nuclear translocation and transmigration in T cells, showing dynein's dual role as a motor and force-transmission element.

The paper models neutrophil navigation through complex chemical gradients using reaction-diffusion equations for Rac and Rho, showing that feedback mechanisms improve motility through narrow and convoluted paths.

The paper shows extracellular mechanical forces influence Golgi secretory function by modulating carrier biogenesis and exocytosis, with molecular determinants including microtubule acetylation and protein kinase D activity.

The paper uses AI-assisted imaging and gene silencing to identify key proteins regulating epithelial tissue mechanics and their roles in cancer.