William F. Dean

This paper identifies a reversible conformational change in the desmoplakin hinge domain in response to mechanical force, showing its role in mechanotransduction within desmosomes.

The paper shows N-cadherin is orientationally ordered at low mechanical load cardiomyocyte junctions but disordered at high load, indicating adaptation to local force conditions.

OOPS is a MATLAB-based software for analyzing fluorescence polarization microscopy images, enabling efficient processing, structure detection, and visualization of polarization data.