Microfluidic and Capillary Electrophoresis Applications

This paper introduces a 3D hydrodynamic flow lithography method to rapidly generate complex microstructures with tailored functionalities.

The paper introduces Selective Laser Etching (SLE) for creating 3D microfluidic and electrochemical devices, demonstrating its use in fabricating functional sliding elements for reconfigurable chips.

The paper introduces a microfluidic device that reduces tissue usage for immunostaining and TME analysis in rare tumors, achieving >90% reduction in section usage and enabling comprehensive biomarker detection.

This paper introduces a deterministic DNA barcoding method using vacuum-driven microfluidics to load oligonucleotides into microwells, achieving uniform barcoding with reduced reagent use and cross-contamination.

This paper introduces a macroscope for wide-field fluorescence imaging in microfluidic devices, achieving high sensitivity and temporal resolution over a large area.

The paper introduces magnetic nanocultures for isolating and growing environmental microbes under near-native conditions, demonstrating their feasibility for discovering uncultured species.

The paper introduces VacTrap, a microfluidic device that isolates and spatially indexes single nuclei from mammalian cells with high efficiency, enabling single-cell multiomics applications.

The paper introduces SplitBlot, a microfluidic single-cell assay that pairs genomic DNA analysis with nucleo-cytoplasmic protein measurements from the same cell.

This paper develops a thermoplastic microfluidic device for automated blood analysis, demonstrating plasma extraction and simultaneous detection of glucose, lactate, and H2O2 with performance comparable to standard methods.

The paper develops a 3D-printed microfluidic device with cascaded nozzles to control multilayered co-axial flows, achieving a minimal delay time and reduced backflow index.

The paper develops an on-chip fluorescence anisotropy immunoassay for human C-peptide by optimizing antibody-tracer pairs to achieve high sensitivity and fast kinetics for microfluidic measurement.

This paper introduces microvalve-based devices for flow-free gradient generation, enabling precise control and automation of microfluidic experiments.

This paper introduces a microfluidic platform for extracting and analyzing bacterial genomic DNA without fragmentation, demonstrating its use on B. subtilis cells.

This paper introduces a low-cost microfabrication method using 3D printing and repurposed microscopes for biological applications, achieving micrometer precision without clean room infrastructure.

The paper develops a microfluidic device for simultaneous proteomic and genomic analysis of microbial samples, showing it can process low-abundant samples with reduced bias.

The paper develops a microfluidic assay to study ATP metabolism tradeoffs in HaCaT cells under hypoxia and hyperglycemia, revealing a metabolic switch between stationary and motile modes.

This paper demonstrates the implementation of trigger valves in open-channel microfluidic systems and develops a model to describe their flow dynamics.

This study investigates how an interleaving oil layer affects the electrotransfer of charged analytes into a hydrogel, showing increased peak skew and dispersion due to oil viscosity and phase mobility mismatch.

This paper introduces a 5-axis CNC micro-milling machine for prototyping 3D microfluidic channels with high resolution, geometric complexity, and material versatility.

This study examines how SH-SY5Y neuroblastoma cell proliferation is affected by chamber size in microfluidic systems, finding that growth is significantly reduced in chambers smaller than 10 mm in diameter.

This paper develops microfluidic interfaces for chronic fluid access to the brain in mice, enabling precise injection and long-term sampling of CSF and biomarkers.

This paper introduces a miniaturized digestion-chip that replicates human digestion dynamics with high accuracy, enabling efficient and low-cost assessment of bioactive materials.

This study develops a PDMS-based microfluidic device using immobilized pH gradient (IPG) gels to reduce cathodic drift in isoelectric focusing, showing significant improvement over traditional carrier ampholyte methods.

SMORES is a microfluidic device that immobilizes Stentor coeruleus for microscopy and surgery with minimal disruption.

This paper introduces a reversible PDMS-PS bonding technique for microfluidic devices, enabling stable cell culture and gentle live cell extraction for downstream applications.

This paper describes a method to directly encapsulate biomolecules in semi-permeable microcapsules using double-emulsions, enabling applications in diagnostics and therapeutics.

This paper introduces a new microfabricated neural probe that enables precise, transient-free sampling of brain extracellular fluid biomarkers in vivo and in vitro.

This paper introduces a microfluidic imaging method for long-term, stable, and parallel live-imaging of C. elegans larval development, enabling observation of previously inaccessible processes.

This paper introduces a microfluidic platform for standardized, sensitive ChIP-Seq on low-input samples, enabling high-throughput and reproducible epigenetic profiling.

This paper describes a valveless microfluidic device for isolating and sequencing single cancer cells, achieving high-quality genome coverage with minimal contamination.