Angiogenesis and VEGF in Cancer

This study shows that a single tyrosine mutation in VE-cadherin increases S1PR1 expression via FOXF1 binding, stabilizing lung vessels in mice.

This paper develops a Tamoxifen-inducible vWF Cre recombinase mouse strain to study microvascular endothelial cell-specific gene function in vivo.

The paper develops a computational model to analyze EC migration during vascular remodelling, finding that directional migration is driven by dual force fields and mediated by Cdc42 with cell population heterogeneity.

This study shows that PCSK9 inhibition enhances anti-angiogenic therapy effectiveness in colorectal cancer liver metastases with vessel co-option.

This study shows DCBLD1 regulates VEGFR-2 endocytosis in endothelial cells, promoting angiogenesis and suggesting it as a therapeutic target for ischemic cardiovascular diseases.

The paper analyzes RNA-seq data to identify key biological processes and signaling pathways in TCF21-overexpressed tumor pericytes, highlighting MAPK and complement/coagulation pathways and several interacting molecules.

This study shows that inhibiting prolyl hydroxylases with DMOG impairs angiogenic competence of human vascular endothelial cells through metabolic reprogramming.

This study shows endostatin inhibits epimorphic regeneration in mice by blocking bone marrow-derived CD31+ endothelial precursor recruitment, unlike its effect on wound repair.

This study shows ATP6AP2 is essential for endothelial cell polarity and extracellular matrix production during both normal and disease-related blood vessel growth.

This study identifies Nucleolin as a factor reactivated in gliomas that promotes angiogenesis and endothelial metabolism by regulating glycolysis through p53-TIGAR-HK2.

This study identifies TUBB8 as the molecular target of benzimidazoles, revealing their mechanism of vascular disruption and potential clinical applications.

This study identifies nxhl as a novel upstream regulator of VE-PTP in angiogenesis by interacting with NCL, revealing a new signaling pathway with therapeutic potential for angiogenesis-dependent diseases.

This study shows that ETS1 and ETS2 redundantly regulate M-phase progression and cell survival in post-natal angiogenesis by controlling G2/M regulators and anti-apoptotic genes.

This study shows that Caspase-8 promotes angiogenesis in endothelial cells through a cell death-independent mechanism involving p38 MAPK activation and VE-cadherin destabilization.

The paper proposes and analyzes a VEGF reaction-diffusion mechanism for tip cell selection in angiogenesis, showing variable tip cell densities based on local VEGF production rates.

The paper investigates the roles of foxc1a and foxc1b in regulating angiogenesis from arteries and veins in zebrafish by modulating VEGF and Dll4/Notch signaling.

This study shows that excess estrogen signaling during development causes vascular malformations in zebrafish by disrupting Hh/Vegf/Notch signaling and promoting aberrant endothelial cell behavior.