Muscle Physiology and Disorders

This paper identifies human muscle reserve cells (MuRC) subpopulations using intracellular autofluorescence, finding that AFHigh cells are enriched in Pax7High cells with delayed activation and slower proliferation.

This study develops an in vivo rheological method to assess skeletal muscle stiffness and elasticity in dystrophin-deficient mice, finding increased stiffness and impaired recovery in mdx mice.

This study presents a spatiotemporal multi-omics analysis of aging neuromuscular junctions in mice, identifying genes with decoupled transcript and protein trajectories and highlighting post-transcriptional regulation in NMJ aging.

This study shows that laminin-α2 secreted by muscle stem cells is critical for their expansion and regeneration, and its loss leads to muscle stem cell dysfunction in LAMA2-related muscular dystrophy.

The paper generates and characterizes the first mouse model with a dominant-negative glycine substitution in collagen VI alpha chains, showing key disease features for therapeutic research.

The paper shows mini-agrin prevents calcium leakage and restores the dystrophin complex in dystrophic muscle cells by stabilizing CaV1.1 and reconstituting dystrophin complex components.

This study identifies mitochondrial respiratory chain dysfunction and reverse electron transfer as key drivers of DUX4-induced toxicity in FSHD, suggesting RET inhibition as a therapeutic target.

This paper investigates how piperine affects resting thick filament activation and dynamic contractility in fast and slow rat skeletal muscles, finding fiber-type-dependent enhancements in contractile function.

This paper shows that injecting a cobalt oxide time-release ion matrix (CoO-TRIM) accelerates skeletal muscle regeneration in injured mice without affecting healthy muscle.

The paper investigates muscle remodeling in NSCLC patients, identifying changes in fibro-adipogenic progenitors, mitochondrial function, and immune cells that contribute to muscle wasting.

Muscle-specific XBP1 deletion or IRE1α inhibition with 4μ8C preserves muscle mass and strength in KPC pancreatic cachexia mice, curbing proteolysis, STAT3 signaling and fatty acid oxidation.

This study shows that MyoMed-205, a small-molecule targeting MuRF1, prevents diaphragm atrophy and dysfunction after 12 hours of unilateral denervation in rats by enhancing muscle structure, function, and reducing fibrosis.

This study investigates the role of fast Myosin Binding Protein-C (fMyBP-C) in skeletal muscle homeostasis across age and disease states using mouse models, finding it critical for muscle function and showing its potential as a therapeutic target.

This study compares the progression of skeletal muscle atrophy caused by fasting and disuse across different muscle fiber types using transcriptomic analysis.

This study uses single-nucleus RNA-sequencing to analyze muscle adaptation in trained and untrained mice, showing divergent cellular responses and improved recovery with prior training.

This study identifies MBOAT2 as a key enzyme that limits PUFA in PC and promotes muscle regeneration in dystrophic and neonatal muscle.

This paper investigates the role of mitochondrial ROS in skeletal muscle atrophy during ovarian cancer and finds that SkQ1 reduces mitochondrial-linked apoptosis but not necroptosis or atrophy.

This study identifies a Netrin-1 signaling pathway that regulates muscle stem cell protrusion dynamics and quiescence maintenance through cytoskeletal components.

This study uses R405W desmin knock-in mice to identify mitochondrial dysfunction, protein quality control issues, and myofibrillar structural changes in myofibrillar myopathy.

This study examines age-related differences in myonuclear multi-omic responses to muscle hypertrophy in mice, identifying transcriptional, epigenetic, and regulatory mechanisms underlying age-dependent muscle plasticity.

This study shows that PDCD4 depletion in myotubes increases myofibrillar protein accumulation but reduces protein synthesis, linked to metabolic changes and reduced ATP levels.

This study compares transcriptomic profiles of in vitro human skeletal muscle models with in vivo references to identify discrepancies and suggest improvements.

The paper characterizes CDK4/hTERT-immortalized ovine satellite cells through multi-omics analysis, showing molecular changes and preserved myogenic traits relevant for cultivated meat.

This study identifies SIRT2 as a regulator of stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling, showing protective effects in mice.

This study investigates the effects of beta-hydroxybutyrate (BHB) supplementation in DMD disease models, showing reduced muscle damage and improved muscle function without adverse effects.

This study identifies collagen VI as a conserved pro-fibrotic factor that impairs muscle regeneration in three distinct human myopathies.

This study shows that short-term hindlimb immobilization in rats causes neuromuscular junction (NMJ) transmission defects, leading to muscle weakness disproportionate to atrophy.

This study shows that reduced RyR1 in muscle spindles of mice with recessive Ryr1 mutations causes proprioception issues and scoliosis.

This study characterizes gait kinematics and muscle function in a BMD pig model, finding altered hip range of motion and muscle fiber changes in flexor muscles.