Memory and Neural Mechanisms

The paper identifies a neural mechanism in the ventral hippocampus that stabilizes aversive beliefs during extinction learning by suppressing adaptive behavioral changes.

This study introduces a temporally structured olfactory task for mice to isolate relational structure from sensory cues and reward, showing that dopamine prediction errors and ventral hippocampal activity are linked to learned temporal structures.

This study shows that optogenetic stimulation of cerebellar Purkinje cells disrupts freezing behaviors and increases aversion to predator-like stimuli.

The paper predicts individual differences in fear and cognitive learning and extinction using multimodal neural connectivity patterns from a large dataset.

This study shows that forgetting arises from reorganization of engram topology during consolidation and identifies engram core contamination as a network-level substrate for forgetting.

This study shows rats use hierarchical composition to construct adaptive action sequences in an open-ended setting, with prefrontal neural representations following a universal geometric format.

This study shows that during conditioning tasks, hippocampal activity shifts from spatial to temporally structured patterns, disrupting place coding in rats.

This study shows that mid-superior temporal sulcus (mSTS) neurons in macaques encode spatial context and behavioral state during natural, unconstrained exploration.

This study investigates whether preserved hippocampal-midbrain function during novelty and expectation processing underlies superior memory in superagers compared to typical older adults.

This study investigates how different DBS frequencies and targets affect memory performance and identifies two dissociated mechanisms underlying these effects.

The paper investigates whether medial prefrontal cortex specialization is representational or computational, finding domain-invariant computations across spatial, social, and sequential domains.

The paper shows that risk alters amygdala activity patterns during reward choice, leading to behavioral flexibility.

The paper investigates how global brain states modulate hippocampal responses to event boundaries and their relation to memory formation.

The paper identifies a new hippocampal neuron subpopulation that supports flexible interval timing through persistent activity and temporal scaling.

The paper shows the entorhinal cortex encodes a cognitive map of social networks, enabling social navigation and information diffusion tracking.

The paper identifies two distinct engram ensembles within striatal medium spiny neurons that encode opposing memories for alcohol relapse and extinction.

The paper shows that silent hippocampal engrams, which persist without memory recall, enhance the consolidation of new memories when reactivated.

The paper develops a biophysically detailed model to show that disinhibition drives memory consolidation during sleep, with replays and ripples playing key roles, and identifies therapeutic strategies for memory disorders.

The paper shows that reducing Cdk5 gene expression via epigenetic editing impairs memory in both male and female mice, highlighting sex-independent epigenetic regulation of hippocampal memory.

The paper investigates replay detection using TDLM and MEG during post-learning resting states and finds no evidence of replay, suggesting methodological limitations in detecting low-density replay events.

This paper identifies a generalized spatial distance-to-goal signal in the nucleus accumbens that enables flexible goal-directed behavior across varying environments.

The paper investigates how stress affects fear memory engrams in the dorsal and ventral dentate gyrus using the SEFL model and FosTRAP2 mice, finding stress enhances reactivation in the caudal DG but not the rostral DG.

This study develops a phenomenological model of memory consolidation that describes it as a brain-wide process involving representational drift and provides a functional interpretation of drift as a mechanism for improved memory retention.

This study investigates sex-specific effects of Cacna1c deletion in D1-expressing cells on fear and spatial memory in mice, revealing differential impacts on male and female behavior.

The paper proposes a theory called Disco to explain subicular neural coding by framing activity as discontinuity signals in continuous experience.

This study investigates how spatial and semantic memory are organized along the hippocampus's long axis using fMRI and eye tracking, finding a combination of gradient and modular dynamics.

The paper shows how excitation-inhibition balance, neural heterogeneities, and trial-to-trial variability jointly regulate spatial information transfer in recurrent place-cell networks.

The paper shows children maintain hippocampal activity patterns related to motor learning longer during post-task rest than adults, suggesting enhanced reactivation supports their better memory consolidation.