Memory and Neural Mechanisms

This paper proposes a system-level theory of MEC-HC wiring to explain how grid and place cell patterns enable cue-triggered goal retrieval and path planning, validated through simulations.

This paper develops a transformer model to decode specific memories from human neuronal activity before and after sleep, finding differential contributions from brain regions.

This study shows that marmosets, like rodents, alternate between locomotion and pauses during navigation, with SWR rates increasing during pauses and memory-guided navigation.

The paper identifies large sharp-wave ripples (SWRs) that enhance memory reactivation and consolidation in mice by improving hippocampal and prefrontal cortex coordination during sleep.

This study identifies a top-down pathway from the anterior cingulate cortex to the retrosplenial cortex that encodes reward-context associations and shapes hippocampal saliency maps.

This study investigates the role of amygdala to ventrolateral prefrontal cortex (vlPFC) projections in contingent learning by inhibiting these connections in macaques and observing effects on reward signaling and choice memory.

The paper shows that visual cortex maintains sensory discrimination regardless of behavior, while the hippocampal dentate gyrus requires active navigation for effective discrimination.

This study tests whether reactivating a motor memory affects its susceptibility to interference from competing learning, finding that reactivation reduces interference when the competing memory cannot stabilize.

The paper investigates how spatial reference frames differ between the postrhinal cortex (POR) and medial entorhinal cortex (MEC) during place navigation in rats, finding that POR neurons adapt to visual landmarks while MEC neurons maintain a stable allocentric representation.

This study investigates how costly avoidance affects the modulation and extinction of visceral pain-related fear, finding that avoidance maintains fear and may hinder extinction.

The paper identifies distinct anterior-posterior subregions in the mouse retrosplenial cortex specialized for different visuospatial processing tasks.

This study shows that hippocampal neurons use both linear and nonlinear computations to encode perceptual and memory information, challenging the traditional spatial vs. non-spatial dichotomy.

The paper identifies transcriptional changes in the avian brain during visual imprinting using single-nucleus RNA sequencing, revealing cell clusters and lncRNAs linked to memory formation.

This study examines how adolescent brains process threat and safety cues, finding a shift from hippocampus-dependent to hippocampus-vmPFC network-dependent safety discrimination as adolescents age.

This study examines how reactivating threat conditioning memory in humans affects emotional memory and cognitive biases, showing that post-reactivation interventions can reduce physiological and cognitive responses.

The paper investigates the parallel development of perisomatic inhibition and ripples in the CA3 and CA1 hippocampal regions, showing they mature together with distinct timing and properties.

This study investigates how movement transitions, speed, and acceleration modulate hippocampal theta oscillations in rats using a controlled treadmill setup, finding that speed, not acceleration, primarily modulates theta frequency.

This study shows that ACC neurons in mice dynamically reorganize their responses to fear cues over time, reflecting changes in novelty and negative valence.

This study shows that Fos labels excitatory neurons specific for memory retrieval, not those activated during memory encoding.

The paper identifies prefrontal projection neurons recruited during remote memory consolidation through synaptic activity of learning-activated cells.

This paper introduces a generalized BTSP rule for neural network learning and shows it can perform unsupervised and supervised tasks but faces challenges with network depth.

This paper identifies replay activity in human infants, showing sequential and temporally compressed reactivation of memory contents at 10 months old.

This study shows that vagus nerve-mediated acetylcholine release in the dorsal hippocampus supports memory function, and its disruption contributes to obesity-induced cognitive impairments.

This study shows that mice do not uniformly express defensive behaviors when exposed to predators, instead showing context-dependent and variable responses.

This study shows that experience-dependent increases in hippocampal sharp-wave ripples are disrupted in 5xFAD Alzheimer's disease mice, suggesting non-cholinergic pathological changes.

This paper investigates how hippocampal theta oscillations respond to different motor behaviors, finding distinct relationships between theta frequency, movement speed, and paw actions during string pulling versus running.

This study shows that stress causes the ventral hippocampus to encode distinct social behavior states, with different neural ensembles for aggression and social hesitancy.

The paper identifies a slow-breathing recovery state in mice after threat avoidance, linked to hippocampal replay of aversive experiences and impaired by SWR suppression.

This study investigates how hippocampal-prefrontal circuits represent emotion knowledge through functional MRI and computational modeling of emotional experiences.

The paper replicates and extends a negative correlation between hippocampal activation during a verbal memory task and subsequent verbal memory test performance.