Iron Metabolism and Disorders

This study investigates how iron homeostasis affects the microbiome-Gut-Brain-Axis (mGBA) communication and reproductive success in Anopheles culicifacies mosquitoes.

This study investigates the role of an N-terminal amphipathic helix in Nramp transporters, showing it regulates conformational dynamics and metal ion transport.

The paper identifies African-specific genetic loci associated with iron status and risk of severe malaria and bacteremia in children, highlighting limited transferability of European polygenic risk scores.

This study shows that Dmt1 deficiency disrupts iron homeostasis, leading to lysosomal dysfunction and impaired Notch signaling by affecting NICD1 degradation and transcriptional activation.

The paper shows that iron availability affects hepatocyte identity in HepG2 cells by modulating HNF4A-driven transcription.

The paper identifies osteocytes as a source of erythroferrone (Erfe) that suppresses liver hepcidin during stress erythropoiesis.

This study shows that frataxin deficiency causes tissue-specific iron homeostasis changes in FXNI151F mice, with brain iron overload and cardiac iron deficiency responses.

This study shows that a high glucose diet causes hepatic iron overload in mice, disrupting iron regulation and contributing to metabolic dysfunction, with potential therapeutic implications for iron chelation and metformin use.

This study investigates how Nrf2 disruption affects iron metabolism in myocardial infarction by examining its role in the Nrf2/hepcidin/ferroportin axis and ferritinophagy in cardiac cells.

The paper identifies SETD2 as a regulator of iron metabolism by modulating ferritin breakdown, affecting cellular iron levels and ferroptosis resistance.

This study investigates the uptake and metabolic fate of two iron-carbohydrate complexes in macrophages, revealing distinct intracellular behaviors that affect their therapeutic outcomes.

The paper shows that mitochondrial iron transport via MFRN1 is essential for erythroid cell cycle progression and terminal differentiation.

This study shows that labile Fe(II) is stored in lysosomes and transported along axons and dendrites in hippocampal neurons, with a method to quantify its distribution.

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

This study shows FAM210B regulates iron homeostasis and sex-specific responses in stress erythropoiesis, with defects in spleen size and blood cell counts in knockout mice.

This study compares the effects of dietary iron deprivation and supplementation in a murine colitis model, finding both worsen inflammation and gut dysbiosis compared to adequate iron diets.

This study investigates the effects of iron deficiency and overload on SARS-CoV-2 lung infection in mice, finding modest inflammatory changes but no significant disease exacerbation.

This study examines sex differences in associations between systemic iron, inflammation markers, and subcortical brain iron levels in older adults.

The paper investigates how glycerophospholipids influence SLC40A1 conformational changes and identifies key residues linked to ferroportin disease.

This study shows PKC inhibition reduces iron overload in diabetes and hemochromatosis by modulating ferroportin expression and trafficking.

The paper investigates diurnal regulation of IRE-containing mRNAs via IRP1 and IRP2 in mouse liver, showing that feeding rhythms drive rhythmicity even without a functional circadian clock.

This study shows neuronal iron deficiency disrupts thyroid hormone-regulated gene expression in developing hippocampal neurons, with some effects persisting after iron repletion.

This study investigates how erythroferrone (ERFE) oligomerization affects its ability to inhibit BMP ligands, identifying a critical ligand binding domain essential for BMP antagonism.

This study shows that amyloid-β exposure in astrocytes increases apo-transferrin levels, which enhances iron transport from endothelial cells at the blood-brain barrier, contributing to early iron accumulation in Alzheimer's disease.

The paper examines how autolysis affects iron storage in ferritins of neurons and glial cells in the human brain, showing differential iron loss rates and cell-type-specific ferritin accumulation.

This study examines sex-specific transcriptome changes in adult rat hippocampus due to early-life iron deficiency and prenatal choline treatment, finding greater effects in females.

The paper develops a computational model of ferritin iron sequestration kinetics, validated against experimental data, showing FT concentration and saturation impact sequestration dynamics.

This study estimates the global carrier frequency and genetic prevalence of IRIDA using gnomAD data, finding a higher prevalence than previously thought.

The paper examines ferritin mRNA density and distribution in hippocampal astrocytes under different iron overload conditions and finds changes in mRNA ratios and localization.