Regulation of Appetite and Obesity

A neural circuit for rapid control of hunger by arousal.

The paper identifies a neural circuit involving hypocretin/orexin neurons that rapidly suppresses hunger through a GABAergic relay, enabling dynamic regulation of hunger based on arousal.

Thalamo-insular basis for updating physiological needs

This study shows that thalamic inputs to the insular cortex update representations of physiological needs like thirst and hunger, and that inhibiting these inputs prevents such updates.

Functional characterization of the 26RFa/orexin neurons of the lateral hypothalamic area reveals their key role in the control of glucose homeostasis

The paper functionally characterizes 26RFa/orexin neurons in the lateral hypothalamic area and finds they regulate glucose homeostasis through coordinated neuropeptidergic signaling.

Central platelet-rich plasma administration promotes weight loss in diet-induced obese mice

This study shows that central PRP administration reduces body weight and improves metabolic parameters in diet-induced obese mice through hypothalamic effects.

Parathyroid Hormone Receptor 1 Signaling Encodes Multifaceted Metabolic Programs in AgRP Neurons

This study identifies PTH1R signaling in AgRP neurons as a mechanism controlling feeding behavior and nutrient partitioning through distinct kinase activation and lipophagic processes.

Astrocyte fatty acid uptake and ketogenesis in the mediobasal hypothalamus coordinate adaptive metabolic responses against high-fat diet exposure in male rodents

This study shows that MBH astrocyte lipid metabolism, specifically fatty acid uptake and ketogenesis, plays a key role in regulating energy balance and mitigating high-fat diet-induced obesity in male rodents.

Postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC dependent signaling.

This study shows that postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC-dependent signaling pathway, which is sexually dimorphic and disrupted in obesity.

Intersectional genetic targeting of molecularly distinct melanin-concentrating hormone neuron subpopulations reveals distinct and overlapping subcircuit architecture

The paper identifies two molecularly distinct MCH neuron subpopulations in the LHA and characterizes their unique and overlapping anatomical projections using genetic and imaging approaches.

A Hypothalamic Pathway for Energy Conservation

This study identifies a hypothalamic pathway involving ARCAgRP neurons and the MnPO that triggers energy conservation during fasting.