Francesco Prisco

This study shows that Tet2-mutant clonal hematopoiesis promotes while Dnmt3a-mutant clonal hematopoiesis inhibits breast cancer progression with age, identifying IL-1/CXCL2 inflammation as a therapeutic target.

This study shows that MBH astrocyte lipid metabolism, specifically fatty acid uptake and ketogenesis, plays a key role in regulating energy balance and mitigating high-fat diet-induced obesity in male rodents.

This study identifies Tmem117 as an oligodendrocyte-enriched regulator of NCX activity, linking myelin homeostasis to counterregulatory response and metabolic health.

This study identifies GM-CSF-producing helper T cells as drivers of immunopathology, showing Treg cells restrain them to prevent tissue damage in mice.

The paper identifies monocyte-derived cells as the primary source of ROS-mediated oxidative tissue damage in neuroinflammation, distinct from microglia.