Microtubule and mitosis dynamics

This study shows that microtubule lattice conformation and integrity regulate TAT1-mediated α-tubulin acetylation, with expanded lattices enhancing acetylation and compacted lattices reducing it.

The paper shows telomeric heterochromatin promotes meiotic centromere assembly by recruiting Aurora B kinase through Swi6HP1 and Haspin-dependent phosphorylation of centromere proteins.

The paper identifies AKIP1 as a novel inner scaffold component essential for centriole integrity through functional genomic analysis and imaging.

The paper identifies a non-autonomous role for somatic cells in maintaining germline incomplete cytokinesis through FGF signaling in Drosophila.

This study identifies the structural basis of βKNL2 centromeric targeting and its role in plant-specific kinetochore assembly, showing its dependence on the SANTA domain and interactions with centromeric DNA and KNL2.

This study shows that TORC1 modulates cohesin functions in chromosome segregation and gene expression, linking environmental changes to chromosome stability.

The paper shows importin-β1 senses Ran-GTP gradients to position the contractile ring during cytokinesis, with effects dependent on cell ploidy.

The paper investigates the protection of Rec8 cohesin during meiosis II by analyzing the roles of Sgo1 and Moa1 in fission yeast.

The paper maps the ordered molecular events of SAC silencing at single kinetochores using MAD2 levels, revealing sequential unbinding, structural reorganization, and stabilization processes.

This study identifies the molecular mechanisms that distinguish meiotic cohesin paralogs from their mitotic counterparts in Schizosaccharomyces pombe, showing why mitotic proteins cannot fulfill meiotic functions.

This study identifies CAMSAP2 condensates as a γ-TuRC-independent mechanism for non-centrosomal microtubule nucleation through phase separation and tubulin organization.

This paper investigates ultrafast contraction in Spirostomum using myonemes, showing centrin-Sfi1 structures drive calcium-triggered contraction without actomyosin or ATP.

The paper shows phosphorylation remodels centrosome matrix proteins to create docking sites for gamma-tubulin complexes, enabling microtubule nucleation during mitosis.

This paper shows that both excess and insufficient MCAK/Kif2C levels disrupt k-fiber turnover and increase chromosome segregation errors by altering tubulin ratios and MT interactions at kinetochores.

This study identifies a critical segment in SKA3's C-terminus that mediates interaction between SKA and NDC80 complexes, essential for metaphase-to-anaphase transition in mitosis.

This study shows that kinetochore proteins in Drosophila and human cells support Golgi assembly and microtubule dynamics in quiescent neural stem cells.

This study shows Scm3 interacts with N-terminal Cse4 to stabilize kinetochore assembly in budding yeast and suggests implications for human disease.

The paper shows that temporal changes in surface tension at the growing tip of Arabidopsis zygotes maintain cortical microtubule bands, which guide the formation of the preprophase band and ensure asymmetric cell division.

The paper shows elevated temperature disrupts nuclear divisions in Drosophila embryos, leading to developmental defects and lethality, with F-actin-microtubule interactions being a key vulnerability.

The paper identifies the SKA complex as a mitotic vulnerability in chromosomally unstable cancers, showing its selective impact on these cells through prolonged mitosis.

The paper measures ATP gradients in motor-microtubule assemblies and shows they are sustained by energy consumption, with implications for cytoskeletal organization.

This study identifies structural switches in tubulin that Taxol exploits to stabilize microtubules by reverting them to a pre-hydrolysis state.

This study shows that KATANIN p60 is essential for forming complete preprophase bands in maize, which is necessary for proper division positioning of subsidiary mother cells.

The paper investigates how the P3018S mutation in dynein affects its function, revealing that the trailing motor in multi-dynein assemblies dictates ensemble velocity.

This study identifies Profilin 1 as a safeguard against genome doubling and polyploidy in cancer by showing its role in maintaining cell cycle fidelity and preventing therapeutic resistance.

This study identifies a non-centrosomal microtubule-organizing center (ncMTOC) in Drosophila oocytes that is essential for nuclear positioning during early oogenesis.

This study shows that Greatwall kinase coordinates meiotic divisions by regulating PP2A-B55, which controls APC/C and Mos/MAPK pathways in Xenopus oocytes.

This study identifies Plasmodium NEK4 as a key regulator that couples meiotic initiation with zygote morphogenesis in malaria parasites.

The paper uses live-imaging to study proliferation dynamics of post-WGD HCT116 cell lineages, finding that multipolar chromosome segregation limits proliferative capacity.