Ion channel regulation and function

The paper investigates how combinations of Nav1.7 and Nav1.8 channels affect nociceptor excitability, showing that their synergistic effects vary across neuronal subtypes.

This study shows ORL-1 interacts with Cav1.2, reducing its membrane expression without changing its biophysical properties.

This study shows that loss of either SUR1 or Kir6.2 subunits in neurons increases dorsal root ganglion excitability and reduces morphine antinociception in mice.

This study identifies the binding site of CVN293 on THIK-1 K2P channel and reveals its allosteric inhibition mechanism through cryoEM structures and functional validation.

This paper introduces a minimal-state kinetic model to compare Kv channel activation currents by simplifying complex kinetic schemes and capturing essential features with few parameters.

The paper investigates functional properties of KCNH1 variants linked to neurodevelopmental disorders, finding most exhibit gain-of-function characteristics.

This study uses molecular dynamics simulations to investigate how extracellular acidification affects the structure and function of HCN2 channels by disrupting hydrogen bond networks involving residue E212.

The paper links experimentally observed ion flux with microscopic mechanistic properties of ion channels by analyzing how voltage and chemical potential affect transport, identifying the rate-limiting step.

This study compares the effects of Nav1.7 and Nav1.8 inhibitors on human dorsal root ganglion neuron excitability, finding Nav1.7 inhibition has larger effects on action potential threshold and upstroke velocity but less impact on repetitive firing.

This study uses molecular dynamics simulations to investigate hERG ion permeation and how small molecules modulate it, revealing structural mechanisms and binding modes.

The paper investigates how α-synuclein interacts differently with VDAC isoforms by analyzing binding kinetics and translocation behavior in planar lipid membranes.

The paper introduces IDIC, a database integrating information on human ion channels and their disease associations, providing annotations and cross-references to biological resources.

This study characterizes GAT1508, a selective neuronal GIRK1/2 activator, showing superior antiepileptic efficacy and synergy with CBD.

The paper identifies affinity hotspots in the modulator pocket of the K2P channel TREK1 by analyzing chemical substitutions and their effects on binding and gating.

The paper identifies KCNA5 mutations under positive selection in colorectal cancer and shows they disrupt channel structure and function, affecting tumor pathways.

This study investigates the impact of the ATP1A3 E815K mutation on human neurons, showing disrupted sodium homeostasis and altered excitability.