Stress Responses and Cortisol

Chronic unpredictable stress induces negative cognitive bias in rats with sex-specific changes in neurogenesis and functional connectivity

Adrenal remodeling encodes stress axis memory to shape fentanyl seeking

This study shows that fentanyl interacts with the HPA axis over different timescales, with adrenal remodeling encoding stress history to influence fentanyl-seeking behavior.

Early dopamine elevation modifies the behavioral consequences of maternal separation in female and male juvenile mice

This study examines how early dopamine elevation interacts with maternal separation in mice, showing sex-specific behavioral and hippocampal volume changes.

EARLY-LIFE STRESS INDUCES SEXUALLY DIMORPHIC BRAIN AGING VIA MESOLIMBIC ALTERATIONS AND FRONTO-STRIATAL DYSFUNCTION

This study shows that prenatal stress leads to different brain aging patterns in male and female mice, affecting behavior and cognition through sex-specific mechanisms involving insulin resistance and hormonal changes.

A mathematical model of the HPA axis demonstrates bifurcations under varying stress and systemic conditions

Behavioral, Cardiovascular, and Neuroinflammatory Effects of 3-Aminobenzamide in a Rodent Model of Chronic Psychological Stress

This study investigates the effects of 3-aminobenzamide (3-AB), a PARP inhibitor, on chronic stress-induced behavioral, cardiovascular, and neuroinflammatory changes in rats, finding protective effects against behavioral deficits and neuroinflammation.

Early-life adversity alters the adult blood proteome primarily in female mice

This study shows that early-life adversity increases IL-17A levels in female mice blood, linking it to autoimmune disease risk, while also affecting other proteins in both sexes.

Sex-Specific Stress Outcomes Following Acute and Chronic Social Defeat Stress

This study investigates sex-specific stress responses to acute and chronic social defeat stress, finding differences in behavioral outcomes between males and females.

Development and cross-tissue validation of a methylation profile score for the cortisol response to stress

The paper develops a methylation profile score to predict cortisol response to stress and validates it across tissues.

The duration of chronic restraint stress protocols does not predict effect sizes in behavioural tests: a meta-analysis

This meta-analysis examines whether the duration of chronic restraint stress affects behavioral test outcomes in rats, finding no correlation between duration and effect sizes.

Fast and Slow Gene Expression Changes in Blood Following Acute Social Stress

This study identifies fast and slow gene expression changes in human blood after acute social stress, revealing distinct immune cell-related transcriptional responses and potential molecular mechanisms linking stress to psychiatric disorders.

Reelin doses normalizing behavioural alterations induced by repeated corticosterone avoid eliciting neuroinflammation-associated morphology in hippocampal microglia

This study shows that reelin administration reverses chronic stress-induced behavioral impairments without causing neuroinflammation in hippocampal microglia in rats.

The obesity associated BDNF intron-3 cis-regulatory element, BE5.1, modulates the effects of early-life stress on weight gain, anxiety and gene expression in a sex dependent manner.

The paper investigates how the BDNF intron-3 cis-regulatory element BE5.1 influences the effects of early-life stress on weight gain, anxiety, and gene expression, showing sex-dependent differences.

The serotonin transporter genotype x cumulative early-life stress interaction has opposite effects on anxiety-like behaviors in male and female rats

This study shows that the SERT genotype interacts with cumulative early-life stress to differentially affect anxiety-like behaviors in male and female rats.

Early life stress alters lifespan trajectories of amygdala development: a cross-species model of amygdala burnout

The paper proposes the amygdala burnout hypothesis, showing early-life stress leads to initial amygdala volume increases in adolescence followed by reductions in older age across rodents and humans.

Stronger brain responses to acute stress reflect greater everyday stress variability

The paper links acute stress brain responses to everyday stress variability, finding greater variability correlates with stronger neural stress responses in specific brain regions.

Disrupted neuropeptide-signaling drives enduring reward deficits after early-life stress

The paper identifies disrupted CRH signaling as a cause of reward deficits after early-life stress and shows CRHR2 activation can reverse anhedonia-like behaviors.

Inhaled black carbon induces depressive-like behavior and enhances stress-related blood-brain molecular vulnerability in mice

This study shows that inhaled black carbon induces depressive-like behavior in mice and enhances molecular vulnerability under chronic stress.

Bile acid signaling as a therapeutically tractable pathway linking early caregiving adversity to social behavior

This study identifies bile acid signaling as a pathway linking early caregiving adversity to social behavior, showing that CDCA supplementation can rescue social deficits in a rat model.

Differential physiological, behavioral, and medial prefrontal cortex transcriptomic responses to chronic restraint stress between BALB/c and C57BL/6J mice

This study compares physiological, behavioral, and transcriptomic responses to chronic restraint stress in BALB/c and C57BL/6J mice, identifying strain-specific molecular signatures related to stress susceptibility.

Adolescent Stress Exposure: Behavioral Consequences and Molecular Mechanisms in Corticolimbic Networks

This study investigates the long-term behavioral and molecular effects of adolescent chronic variable stress in rats, revealing sex- and region-specific changes in corticolimbic circuits.

The king of stress? Exploring the physiological resilience and resistance of adult king penguins to chronic glucocorticoid exposure

This study examines how adult king penguins respond to chronic corticosterone exposure, finding they show resistance and resilience to its negative effects on physiology.

Early-life stress alters chromatin modifications in VTA to prime stress sensitivity

This study shows early-life stress alters chromatin modifications in the VTA, increasing stress sensitivity through changes in histone dynamics and Setd7 activity.

Hypothalamic recurrent inhibition regulates functional states of stress effector neurons.

This study identifies recurrent inhibition as a key circuit motif regulating functional states of stress effector neurons through experimental and computational approaches.

Consequences of Early Postnatal Blockade of Aldosterone Synthesis on Behaviour and Stress Response in Male and Female Rats

This study examines the effects of early postnatal aldosterone synthesis inhibition on behavior and stress response in male and female rats, finding sex-dependent changes in anxiety and adrenocortical regulation.

Inflammatory Proteins are Highly Variable During a Natural Stressor: A Call for Intensive Longitudinal Blood Microsampling

This study shows that inflammatory proteins vary little between individuals over time, highlighting the need for intensive longitudinal sampling to capture dynamic changes in immune responses.

Stressor-specific dynamic patterns of noradrenaline release in the paraventricular nucleus of the hypothalamus in freely moving mice

This study investigates stressor-specific patterns of noradrenaline release in the PVN of freely moving mice using a fluorescent sensor, revealing distinct temporal dynamics across different stressors.

Deep Phenotyping with Global Brain Activity and Plasticity Mapping Identify the Dorsal Raphe-Basolateral Amygdala Circuit as a Mediator of Adaptive Stress Responses

Stressor identity shapes plasma proteomic and metabolic responses in humans

This study shows that different stress types cause distinct plasma proteomic and metabolic responses in humans, with physical stress having the strongest effect.

Slow stress-load accumulation dominates BDNF-dependent gain in a ten-state computational model of stress biochemistry

The paper uses a computational model to show that slow stress-load accumulation, rather than BDNF-dependent feedback, drives coordinated changes in stress pathways under sustained stress.