Neonatal Respiratory Health Research

Natural killer cell TGF- signaling regulates senolytic activity and vascular patterning in the postnatal lung

This study shows that NK cell TGF-β signaling regulates postnatal lung development and BPD by affecting vascular patterning and senolytic activity.

Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

This study shows that Svep1 is essential for proper lung development by regulating airway branching and alveolar differentiation in mice.

Early Tracheal and Salivary miRNAs in Extremely Preterm Infants Predict BPD-related Pulmonary Hypertension

The paper identifies miRNAs in tracheal and salivary samples of preterm infants that predict BPD-related pulmonary hypertension with improved accuracy when combined with clinical variables.

Ductal myofibroblasts reactivate contractile program to stabilize alveolar architecture during lung regeneration

The paper identifies ductal myofibroblasts as critical for maintaining alveolar structure during lung regeneration through reactivation of a contractile program.

Sparse Machine Learning Pipeline with Stabl Identifies Cord Blood Multi-Omic Signatures of Bronchopulmonary Dysplasia

The paper uses a sparse machine learning pipeline to identify multi-omic biomarkers predictive of bronchopulmonary dysplasia in cord blood samples.

Wnt signaling decline drives age-related alveolar stem cell loss and impairs lung repair

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

AP-1 mediated chromatin changes govern alveolar type 2 cell transition in lung injury-repair

The paper identifies AP-1 transcription factors as regulators of a transitional state in lung alveolar type 2 cells during injury-repair, linking chromatin changes to both regeneration and tumorigenesis.

A Bioactive Phospholipid Promotes Rapid Progenitor Lung Progenitor Activation via AP-1

This study identifies lysophosphatidic acid (LPA) as a key bioactive lipid that promotes alveolar type 2 cell progenitor activation via AP-1 transcription factors during lung regeneration.

Co-optation of the regenerative role of type 2 alveolar cells in distal lung repair in mice by terminal airway epithelial cells in humans

This study shows human terminal airway epithelial cells regenerate alveolar type 1 cells without a type 2 intermediate, co-opting the mouse regenerative mechanism.

A human organoid model of alveolar regeneration reveals distinct epithelial responses to interferon-gamma

This study develops a human organoid model to investigate interferon-gamma's effects on alveolar epithelial cell regeneration, showing divergent impacts on AT1 and AT2 cells.

Increased S. epidermidis in the airway-gut microbiome of infants with bronchopulmonary dysplasia

This study identifies increased Staphylococcus epidermidis in the airway-gut microbiome of preterm infants who develop bronchopulmonary dysplasia.

Using Fiji as a simplified tool for assessing alveolar chord length and septal thickness in neonatal pulmonary disease research

The paper develops a Fiji plugin to measure alveolar chord length and septal thickness in BPD research, validated across animal models and human lungs.

Multiscale Computational Modeling of the Cardiopulmonary Consequences of Postnatal Hyperoxia with Implications for Preterm Born Children

This paper develops a multiscale computational model to simulate cardiopulmonary effects of postnatal hyperoxia in rats, showing agreement with experimental data and capturing abnormalities seen in preterm humans.

3-Mercaptopyruvate Sulfurtransferase (MPST) Regulates Mitochondrial Metabolism and Epithelial Differentiation in Neonatal Patient-derived Airway Cells

This study shows that MPST is essential for maintaining mitochondrial metabolic integrity in neonatal airway epithelial cells, and its loss under hyperoxia disrupts epithelial differentiation and contributes to airway injury.

Neonatal regulatory T cells promote alveologenesis by restraining neutrophil-mediated inflammation

This study shows neonatal regulatory T cells support alveologenesis by limiting neutrophil-driven inflammation and maintaining epithelial balance.

Infants who develop BPD have an airway endotype defined by vimentin expression and ciliary loss

The paper develops an ex vivo model of BPD using airway epithelial cells and identifies a molecular endotype characterized by vimentin expression and ciliary loss in infants with BPD.

Lentiviral-mediated gene complementation rescues pathogenic ABCA3 variants

This study tests lentiviral-mediated ABCA3 gene complementation in cell lines with specific pathogenic variants, showing partial rescue of cellular functions and differential effects based on variant type.

An automated morphometric approach to evaluate distal lung patterning in mouse models of Bronchopulmonary Dysplasia

The paper introduces a semi-automated method using Fiji to quantify lung airway and alveolar features in a mouse model of BPD, showing correlations with mean linear intercept and demonstrating structural changes in hyperoxia-exposed mice.

Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through intrinsic apoptosis in the neonatal lung

This study identifies Stc1-expressing myofibroblasts as a distinct lineage that undergoes apoptosis during neonatal lung development, using genetic tools and single-cell RNA-seq.

Quantitative Proteomics Links Mitochondrial Dysfunction to Metabolic Changes and Epithelial Differentiation Defects in Hyperoxia-Exposed Neonatal Airway Cells

This study shows that hyperoxia impairs mitochondrial function and epithelial differentiation in neonatal airway cells through proteomic analysis and metabolic reprogramming.

Umbilical Cord Blood Cell Transcriptional and Methylation Signatures at Birth Are Associated with BPD Development.

The paper identifies transcriptional and methylation signatures in umbilical cord blood linked to BPD risk in preterm infants.

Interplay Between Pulmonary Membrane Properties and Lung Disease: a Study of Seven Bottlenose Dolphins

The paper examines pulmonary surfactant membranes in bottlenose dolphins, linking their structure and lipid composition to lung injury severity and mechanical properties.

Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung

The paper constructs a cellular atlas of the early postnatal human lung and identifies two distinct AT2 cell states linked to inflammatory signaling and clinical interventions.

Hypoxia promotes airway differentiation in the human lung epithelium

This study shows hypoxia promotes airway differentiation in human lung epithelial progenitors through HIF pathways, with implications for lung disease.

Sorted-Cell Proteomics Reveals an AT1-Associated Epithelial Cornification Phenotype and Suggests Endothelial Redox Imbalance in Human Bronchopulmonary Dysplasia

This study uses sorted-cell proteomics to identify BPD-specific proteome changes in epithelial and endothelial cells, revealing cornification-associated proteins and redox imbalance.

Patient-derived airway organoids from BAL fluid model injury and therapy responses in neonatal bronchopulmonary dysplasia

The paper develops patient-derived airway organoids from BAL fluid to model BPD injury and therapy responses in vitro.

A spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity

This paper creates a spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity using 1.2 million cells from 17 human infant lungs.

Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-inducedlung injury

The paper identifies TREM2-p53 signaling as a determinant of oxygen-induced lung injury in mice, showing that TREM2 loss reduces inflammation and improves lung development.

Postnatal Abrogation of VEGFR2 Blocks Terminal Cap2 Differentiation by Preventing the Developmental Progression from a Capillary Intermediate Cell State

This study shows that postnatal VEGFR2 abrogation blocks Cap2 differentiation by preventing the transition from Cap1 to CapINT, impairing alveolarization and activating fibroblasts.

Isoform-Specific Roles of NTRK2 in Pulmonary Vascular Regeneration

The paper identifies an NTRK2 isoform switch in BPD lungs that impairs endothelial regeneration and shows that restoring full-length NTRK2 mRNA can reverse alveolar damage.