Author

M. Martin VandenBroek

Queen's UniversityORCID 0000-0003-4937-2502Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Mark L. OrmistoniD· 3 shared Douglas QuiltyiD· 2 shared Jeffrey D. MewburniD· 2 shared Stephen L. ArcheriD· 2 shared Anna Ryan HemnesiD· 1 shared Anne L. TheilmanniD· 1 shared Ashley Y MartiniD· 1 shared Asish DasguptaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersDevelopmental Biology

Mark L. OrmistonORCID

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3 papers

Recent·Most cited

Developmental BiologyCirculation ResearchPeer-reviewedOct 27, 2026

Natural killer cell TGF- signaling regulates senolytic activity and vascular patterning in the postnatal lung

Declan J. Gainer, Kassandra M. Coyle, Matthew T. Rätsep…·Mark L. Ormiston

This study shows that NK cell TGF-β signaling regulates postnatal lung development and BPD by affecting vascular patterning and senolytic activity.

1 citation

mousebulk RNA-seq

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Molecular BiologyArteriosclerosis Thrombosis and Vascular BiologyPeer-reviewedAug 7, 2025

Circular RNA profiling identifies circ5078 as a BMPR2-derived regulator of endothelial proliferation and stress responses

M. Martin VandenBroek, M.C. Sharp, Patrick Thompson…·Mark L. Ormiston

The paper identifies circ5078 as a BMPR2-derived circular RNA that regulates endothelial proliferation and stress responses in PAH, with opposing effects to linear BMPR2 mRNA.

3 citations

humanbulk RNA-seq

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Pharmacology & ToxicologyHypertensionPeer-reviewedAug 20, 2024

Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension

Danchen Wu, Ross D. Jansen‐van Vuuren, Asish Dasgupta…·Stephen L. Archer

This study evaluates Drpitor1a, a Drp1 inhibitor, showing efficacy in reducing PAH in female rats and human PASMCs without toxicity.

21 citationstop 3%

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