Autophagy in Disease and Therapy

This study shows that axonal mitochondria depletion disrupts autophagy and proteostasis in neurons, mediated by the eIF2β pathway, contributing to aging and neurodegenerative diseases.

The paper shows SQSTM1/p62 accumulates in BHD kidney tumors due to FLCN loss, but is not required for tumor growth.

This study identifies Mfi2, a mitochondrial outer membrane microprotein required for mitophagy, showing that both inner and outer mitofissins are needed for mitochondrial fission during mitophagy.

The paper shows that the R519Q GluN2B variant is degraded via autophagy-lysosomal pathway, providing a mechanism for NMDAR variant clearance and potential therapeutic targets.

This study shows that TMEM55B loss disrupts lipid metabolism by altering lipophagy and mitochondrial function, worsening MASLD in mice.

This study shows that DMMB-induced photodamage causes transcriptomic changes similar to autophagy inhibition and persistent mitochondrial dysfunction.

The paper determines the molecular structure of autophagic cargo condensates using cryo-electron tomography and shows how disordered regions influence condensate properties.

This study identifies ATG8 E3-like ligases as damage sensors that facilitate ESCRT recruitment to repair lysosomal membranes.

This study shows p62/SQSTM1 is essential for starvation-induced autophagy in N2a cells but not for basal autophagy.

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

This study investigates the distinct roles of VMP1 and TMEM41B in hepatic lipoprotein secretion and autophagy, showing that VMP1 has a more critical role in regulating these processes in MASLD.

This study shows that maternal autophagy in maize affects kernel development and grain yield, with mutant plants showing reduced kernel size and yield.

The paper shows that combining elevated neuronal activity with mitochondrial damage increases mitophagy in axons, requiring Pink1.

The paper develops a fluorescence lifetime-based sensor to image autophagy dynamics in vivo, revealing spatial and activity-dependent patterns in the mouse brain.

This study generates a dWDR45 knock-out Drosophila model to investigate autophagy's role in BPAN, finding that autophagy defects contribute to some but not all phenotypes.

The paper identifies an EGFR/TBK1-dependent mitochondrial quality control mechanism that contributes to acquired resistance to temozolomide in glioma cells.

This study shows that autophagy regulates asymmetric inheritance of old mitochondria in CD8+ T cells, which influences their metabolic state and memory potential.

This study shows that disrupting non-canonical autophagy (LANDO) impairs endothelial and cardiac function by disrupting VEGFR2 recycling and Hb- expression.

This study identifies raffinose as a plant autophagy inducer that enhances biomass and yield by promoting autophagy-dependent growth under stress conditions.

This paper identifies WRN's role in regulating mitophagy and autophagy in cancer by resolving G-quadruplexes and R-loops to enable proper ATG7 mRNA processing.

This study shows that coronavirus infection activates lysosomal stress responses and that TFEB and TFE3 regulate viral replication, autophagy, and apoptosis.

This study identifies p62 as a key mediator of UBB+1 secretion via autophagy, revealing a dual role for autophagy in managing neurotoxic proteins.

The paper develops a p62-based biodegrader that selectively degrades mitochondria via autophagy but not cytosolic proteins due to its effect on p62 self-oligomerization.

This study shows that activating AMPK reduces excessive mitophagy and restores mitochondrial function in FBXL4-related mitochondrial DNA depletion syndrome models.

The paper develops a method to isolate autophagosomes from mice and uses proteomics to analyze cargo profiles in skeletal muscle during starvation and exercise, identifying distinct cargo selection patterns.

The paper identifies a conserved selective autophagy receptor, CESAR, critical for proteostasis under heat stress in plants through cross-species interactome analysis.

The paper identifies a metabolic vulnerability in triple-negative breast cancer through sphingolipid metabolism, showing that targeting this pathway with eliglustat reduces tumor growth and improves survival.

This study identifies LLO's role in subverting xenophagy by binding LC3 and inhibiting TFEB, and shows that restoring these functions reduces Listeria monocytogenes infection.

This study shows that TOR and heat shock pathways regulate peroxisome biogenesis during proteotoxic stress in yeast and human cells.

This study determines the cryo-EM structure of p62 and visualizes its filament organization and calcium-rich lipid droplet cargo in cells under stalled autophagy.