Autophagy in Disease and Therapy

This paper shows that activating the MasR receptor with CAP-1902 improves mitochondrial function in a human Complex III deficiency model by enhancing turnover and reducing stress.

This study shows that loss of CMA in mice leads to AMD-like retinal pathology, which is reversed by activating BK channels with GLA-1-1.

This study identifies miR-378a and NPNT as regulators of autophagy in podocytes through mTOR and MAPK signaling, revealing their roles in glomerular disease.

This study identifies ULK1-driven autophagy as a mechanism by which HPV+ HNC cells degrade MHC-I, promoting immune evasion and tumor growth.

This study identifies ULK1-linked mitophagy as a mechanism enabling cardiac hypoxia tolerance in blind mole-rats through metabolic and mitochondrial adaptations.

The paper reports the structure of full-length TECPR1 using cryo-EM, revealing its cis Dysferlin domain architecture and stabilizing intramolecular interface.

This study identifies SPL2 as a mitochondrial E3 ligase that regulates seedling emergence by controlling ER-mitochondrial interactions and mitophagy through ubiquitination of mitochondrial proteins.

This paper introduces a method using thermally activated calcium sulfate (ACS) to induce vacuolization in mammalian cells, enabling a scalable platform for drug screening related to phagocytosis and lysosomal function.

This study develops a physiological CSF-like medium to culture CNS-ALL cells, revealing autophagy as a critical survival mechanism in the CNS niche.

The paper identifies ERK signaling as a suppressor of chaperone-mediated autophagy (CMA) and shows that inhibiting ERK can restore CMA by increasing LAMP-2A expression.

The paper shows Samd14 maintains autophagy balance in red blood cell precursors during acute anemia by interacting with PI3P and modulating VPS34 activity.

This study uses deep learning and time-resolved imaging to map the genetic network controlling autophagy dynamics, revealing a hierarchical control mechanism and new regulatory aspects.

This study shows that phosphatases Ppz1 and Ppz2 suppress potassium influx via Trk1 and Trk2 to enable autophagy in yeast.

This study shows that the Arp2/3 complex is essential for lysosomal integrity during autophagy, as its absence leads to lysosomal damage and impaired autophagic flux.

The paper uses IVIS Lysotracker imaging and RT-qPCR to assess lysosomal abundance and autophagy-related gene expression in young and aged mouse hearts, finding preserved acidic-vesicle pool and stable gene expression.

The paper identifies mitophagy-induced mRNA granules (mitoRGs) that regulate cell fate during PINK1/Parkin mitophagy by controlling PGAM5 activity.

The paper reports the design, synthesis, and characterization of new ULK1/2 inhibitors that inhibit autophagy and upregulate MHC I in NSCLC cells, supporting their potential as cancer therapeutics.

This study shows cyclin C maintains autophagy-lysosome pathway function in pancreatic development and suppresses cancer by eliminating damaged cells, with potential therapeutic implications for pancreatic neoplasms.

This study predicts the impact of all missense variants in ATG9A using structural analysis and variant effect predictors, identifying potentially damaging variants and their molecular mechanisms.

The paper compares lysosomal characteristics between fibroblasts of two mouse species, finding elevated lysosomal mass and enzyme activity in M. spretus compared to M. musculus.

The paper uses a novel fluorescent probe to show reversible phospholipid transfer between ER and autophagosome membranes in vivo.

This study shows that endothelial cell autophagy reduces metastasis in mouse breast and pancreatic neuroendocrine tumor models by delaying tumor growth and increasing apoptosis.

This study identifies PDZD-8 as an ER protein that interacts with LGG-2/LC3 to promote autolysosome formation by bridging ER-autophagosome contacts.

The paper identifies a 2'-deoxycytidine-based compound that activates autophagy and mitophagy, extends C. elegans lifespan when conjugated with a mitochondria-targeting dye.

This study develops capsaicin-derived ligands that modulate the AURKA/PHB2 interaction and mitophagy in cancer cells, with compound 13 showing promise as a specific inhibitor of AURKA-dependent mitophagy.

This paper identifies two short linear motifs in NCOA4 that bind GATE16 with high avidity, enabling ferritinophagy and revealing a mechanism for iron-dependent regulation of this process.

This study identifies STBD1 as a conserved glycophagy receptor in bilaterians, showing its structural evolution supports metabolic adaptation across species.

This study investigates ATG gene duplication in vertebrates, showing that most ATG genes were duplicated via whole-genome events near the vertebrate root and explores functional divergence patterns among paralogs.

This study shows that axonal mitochondria depletion disrupts autophagy and proteostasis in neurons, mediated by the eIF2β pathway, contributing to aging and neurodegenerative diseases.