Autophagy in Disease and Therapy

Ume6 Coordinates Lysosomal Remodeling and Autophagy Through Transcriptional Repression in S. cerevisiae

This study identifies Ume6 as a transcriptional repressor that regulates vacuolar protein composition and autophagy in yeast by interacting with Rph1 and being modulated by protein kinases.

Heat-dependent engagement of a buried mitophagy motif in prohibitin 2

This study shows that a buried LIR motif in PHB2 responds directly to temperature changes, affecting mitophagy and cardiac injury during heat stroke.

FXR2 Promotes Autophagic Clearance of Sindbis Virus Capsid and Protects Against Viral Encephalitis

This study identifies FXR2 as a mediator of autophagy that clears Sindbis virus capsid and protects against viral encephalitis by reducing viral protein toxicity.

AKT1-phosphorylated TERT assembles a FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE

This paper identifies an AKT1-TERT-FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE cells under stress.

MYC Suppresses Mitochondrial Function in Hepatocellular Carcinoma through NRF1-Driven Receptor-Mediated Mitophagy

This study shows MYC suppresses mitochondrial function in HCC by promoting mitophagy via NRF1, and inhibiting this pathway reduces tumor growth.

The WD40 domain of autophagy protein ATG-16.2 is required for lysosomal regulation and longevity in germline-less C. elegans

Non-cell-autonomous removal of protein aggregates via trogocytosis

The paper shows macrophages remove protein aggregates from other cells via trogocytosis, driven by lysosomal stress and tmCSF1 signaling.

Arrested PPTC7 import couples mitochondrial depolarisation to NIX and BNIP3 degradation

The paper shows that mitochondrial depolarisation inhibits PPTC7 import, leading to its degradation and the loss of NIX and BNIP3, thereby switching mitophagy pathways.

Release of BEC-1 from CED-9 stimulates lysosome tubulation in C. elegans by engaging Class III PI3K complex I

This study shows that BEC-1 dissociation from CED-9 in C. elegans promotes lysosomal tubulation and autophagy by activating the Class III PI3K complex I.

Oligodendrocyte ER-phagy Restricts Excessive Myelination by Degrading Sphingolipid Synthases

This study identifies ER-phagy as a negative regulator of myelin sheath thickness by degrading sphingolipid synthases in oligodendrocytes, preventing excessive myelination.

Secretion is a second fate for p62 and is coupled to KEAP1/NRF2 signaling

This study shows p62 can exit cells through secretion, a process linked to KEAP1/NRF2 signaling and distinct from autophagy.

A reversible temperature block captures pre-lysosomal intermediates of starvation-induced ERphagy

This study identifies a reversible temperature block that captures pre-lysosomal intermediates of ERphagy, showing their formation requires autophagy machinery and reveals their structural features.

Complex I Inhibition Redirects Autophagy from Bulk Turnover to Mitochondrial Clearance

This study shows that Complex I inhibition redirects autophagy from bulk turnover to mitochondrial clearance in human cells.

Sarcoplasmic reticulum remodeling through autophagosome biogenesis during Drosophila metamorphosis

This study shows autophagy is essential for sarcoplasmic reticulum remodeling during Drosophila muscle metamorphosis, with SR membranes incorporated into autophagosomes.

Vac8-driven vacuolar remodeling primes mega-autophagy and safeguardsgamete developmental competence

This study identifies Vac8 as a regulator of vacuolar remodeling during meiosis, which primes mega-autophagy to ensure gamete developmental competence.

GlRac Regulates an ATG8-Independent Autophagy-Like Pathway in Giardia lamblia

This study identifies an ATG8-independent autophagy-like pathway in Giardia lamblia regulated by GlRac, showing structural and functional similarities to canonical autophagy despite lacking most ATG genes.

Local ROS and inefficient autophagosome formation limit Optineurin-mediated mitophagy in neurons

In rat hippocampal neurons under mild oxidative stress, Optineurin-marked damaged mitochondria are engulfed slowly and reach lysosomes over days; scavenging mitochondrial reactive oxygen species or nutrient deprivation speeds this.

Autophagy dependent HIF1α proteostasis is compromised in models of PEX1 deficiencies

This study shows that PEX1 deficiencies disrupt HIF1α proteostasis via autophagy, leading to increased HIF1 levels and impaired recovery under hypoxia-reoxygenation.

A family of metabolite damage-control phosphatases modulates ROS-induced autophagy and plant stress resilience

This study identifies RMDPi-1 as an autophagy enhancer that inhibits RMDP phosphatases, increasing ROS and autophagy in plants, thereby improving stress resilience.

Ether glycerophospholipid control of peroxisome degradation confers protection from ischemia

This study identifies FAR1 as a key regulator of peroxisome degradation under hypoxia, linking ether lipid metabolism to autophagy and cardioprotection.

Autophagic flux is increased in peripheral blood mononuclear cells in atherosclerotic vascular disease and associates inversely with adverse cardiovascular events

The paper measures autophagic flux in PBMCs of ASVD patients and finds it is elevated and inversely associated with adverse cardiovascular events.

Box C/D snoRNPs and MDT-15/MED15 regulate mitochondrial surveillance and mitophagy via fatty acid metabolism

LC3 forms functional nanocluster on autophagosome

The paper shows LC3B forms nanoclusters on autophagosomes via specific lipid interactions and a unique binding pocket, impacting autophagosome motility.

Pathogenic mutations in ATAD3A cause dysregulation of RagC/D-TFEB axis and disrupt lysosomal homeostasis

This study shows that pathogenic ATAD3A mutations disrupt the RagC/D-TFEB axis, leading to lysosomal dysfunction and neurodevelopmental defects.

Redox activation of ATG5 licenses autophagy upon nutrient restriction

The paper identifies redox regulation of ATG5's Cys19 as critical for autophagy initiation under nutrient restriction in human cells and mice.

Dynamin-2 promotes Atg9A retrieval from phagophores during autophagy.

This study shows that Dynamin-2 facilitates Atg9A retrieval from phagophores during autophagy by mediating membrane fission, preventing Atg9A degradation in autophagosomes.

Nuclear LC3 Interactome Profiling Identifies Clathrin Heavy Chain as a Mediator of Nuclear LC3 Translocation in Trabecular Meshwork Cells

The paper identifies clathrin heavy chain as a mediator of nuclear LC3 translocation in trabecular meshwork cells and links its dysfunction to glaucoma pathogenesis.

Bacterial lipid effectors subvert host autophagic flux by inducing lysosomal dysfunction

This study shows bacterial lipids from HlyF/CprA virulence factors disrupt lysosomal function and autophagic flux, impairing host clearance.

Lysosomal proteome and lipidome analyses of intestinal cells reveal the crucial role of bis(monoacylglycero)phosphate for autophagosome-lysosome fusion

This study identifies BMP's role in autophagosome-lysosome fusion by analyzing lysosomal proteomes and lipidomes in GNPTAB-deficient intestinal cells.

SIM2s coordinates programmed mitophagy with respiratory chain supercomplex remodeling during mammary epithelial differentiation