Neurogenesis and neuroplasticity mechanisms

This paper demonstrates an in vivo platform for transplanting neocortical tissue prototypes that can differentiate into functional neurons and become vascularized.

This study investigates how adult born granule cells influence pattern separation by modulating remapping of place and cue cells in the hippocampus.

This study tracks oligodendrocyte progenitor cells in zebrafish visual system development, revealing their origin, migration patterns, and transcription factor expression.

This study compares the effects of exogenous and endogenous ECM on neuroepithelial development in human telencephalic organoids, showing rapid polarization with exogenous ECM and gradual acquisition with endogenous ECM.

This study shows that the piRNA pathway is essential for adult neurogenesis by repressing protein synthesis and cellular senescence in mouse hippocampal neural progenitor cells.

This study shows that deleting mTORC2 in oligodendrocyte progenitor cells causes hypomyelination specifically in the corpus callosum, but not the spinal cord.

This study shows that GDF15 regulates proliferation of apical progenitors in the developing murine ganglionic eminence, increasing ependymal cells and neural stem cells.

This study shows that Ascl1 induces low-efficiency neuronal reprogramming of proliferative glia in vivo, unlike its efficient in vitro conversion.

This study shows miR-17~92 has different effects on neural stem cells and transit amplifying cells in the adult mouse V-SVZ, affecting proliferation and lineage commitment.

This study shows human bone marrow-derived mesenchymal cells can transdifferentiate into neural-like cells without cell fusion, forming binucleated cells through nuclear movement.

This study compares phenotypes of Pax6 mutant cerebral organoids with Pax6 mutant mouse embryos, finding similarities in neural differentiation and cell cycle changes.

This paper investigates the anatomical development of the cerebello-thalamic tract in embryonic mice, showing that axons invade the thalamus after E16.5 and establish synapses by E18.5.

This study characterizes the transcriptomic and cellular dynamics of whole CNS regeneration in the tunicate Polycarpa mytiligera, identifying key pathways and markers involved in the process.

The paper uses in vivo proximity labeling to analyze the subcellular proteome of radial glial cells and identifies non-muscle myosins that regulate endfoot structure and interneuron organization.

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

The paper investigates learning-related changes in grey matter and myelin in rodent sensorimotor cortex using MRI and immunohistochemistry, finding non-linear morphometric changes linked to myelin plasticity.

The paper uses live-imaging to show that squid retinal neurogenesis shares vertebrate-like mechanisms, including interkinetic nuclear migration and Notch signaling regulation.

The paper maps transcriptional dynamics in murine cortical development, identifying lineage shifts and gene regulatory networks in neural stem cells, basal progenitors, and newborn neurons.

The paper shows that GABA levels in the adult mouse spinal cord regulate neural stem cell proliferation, with increased GABA reducing proliferation and decreased GABA increasing it.

The paper shows PRC2 has distinct, sequential functions in RGP lineage progression, acting tissue-wide for proliferation and cell-autonomously for astrocyte maturation.

The paper shows that seizures in mice disrupt the hippocampal neurogenic niche by inducing reactive neural stem cells via the EGFR pathway, and inhibiting EGFR improves neurogenesis.

The paper identifies Cut as a regulator of cortex glia growth and endomitosis in Drosophila, impacting neural niche formation and function.

This study identifies ZIC3 as a key regulator of tyrosine hydroxylase expression in dopaminergic neurons of the olfactory bulb and midbrain through dual regulatory mechanisms.

The paper identifies a subset of oligodendrocyte precursor cells (OPCs) that lack Olig2 expression, which is influenced by brain injuries and complex motor learning.

This paper develops a computational model to study how granule cell interactions influence dendritic tree selection in Purkinje cells during cerebellar development.

The paper investigates MYT1L's role in suppressing earlier neuronal development programs in the adult mouse brain, showing it regulates gene expression and chromatin structure in cortical neurons.

This study shows that Foxp1 loss increases angiogenesis and hypoxia in radial glia, altering their metabolic state and neurogenic capacity.

The paper identifies SHH signaling from retinal ganglion cells to thalamic astrocytes as essential for GABAergic interneuron migration into the visual thalamus.

This study identifies Tensin3 as a critical regulator of oligodendrocyte differentiation by mediating integrin-β1 survival signaling during morphological changes.

The paper shows that a bHLH circuit enables neural stem cells to choose astrocytic fate by integrating BMP and LIF signals and suppressing alternative fates.