Neurogenesis and neuroplasticity mechanisms

The paper shows ADAM10 regulates macroglial cell fate by promoting astrocyte generation and inhibiting oligodendrocyte production in developing brains.

This study identifies TERT-expressing cells as a novel multipotent stem cell population in the adult mouse brain, capable of differentiating into multiple cell types.

This study shows hypoxia promotes neurogenesis in human fetal neural stem cells by activating the WNT pathway through upregulation of neuronal markers and downstream WNT targets.

This study shows that Rac1 and Rac3 are essential for cortical interneuron migration and axon growth, with TPC2 contributing to the phenotype by affecting axonogenesis and migration.

This study uses single-nucleus RNA sequencing to show that erythropoietin treatment restructures transcriptional networks in hippocampal pyramidal neurons, increasing their numbers and altering gene expression related to neurodifferentiation and cognition.

This study shows that myelin in the adult mouse median eminence continuously turns over, regulated by nutritional status and microglia.

This paper develops a pharmacogenetic model to ablate oligodendrocyte progenitor cells (OPCs) in adult mice, achieving 98.6% depletion and revealing compensatory mechanisms from V-SVZ-derived NPCs.

This study identifies a BMP signaling wave that drives anteroposterior specification of the tuberal hypothalamus in chicken embryos.

This study shows that bictegravir inhibits oligodendrocyte maturation by causing lysosomal de-acidification, which can be reversed by activating TRPML1.

This study shows that elevated glucocorticoid exposure during zebrafish development disrupts hypothalamic neurogenesis, leading to developmental abnormalities and reduced survival.

This study shows microglia maintain homeostasis in the developing RMS by phagocytosing neuroblasts, with depletion causing RMS abnormalities and increased apoptosis.

This study shows that high-fat diet feeding in adult zebrafish causes brain inflammation, neuron loss, and regenerative responses, with potential implications for treating obesity-related brain injuries.

The paper shows that oligodendrocyte production is crucial for improving working memory performance in mice during maze training.

This study shows that repeated concussive-like injuries in mice impair the neurogenic response, leading to cognitive deficits and suggesting potential therapeutic targets for repeated brain injury.

This paper identifies transcriptomic signatures and functional pathways disrupted in Drosophila asp mutants, revealing roles for temporal transcription factors and inflammation in microcephaly.

This study shows that aerobic training improves cognitive performance and neurogenesis in middle-aged mice, with effects influenced by sex and BDNF Val66Met genotype.

This study shows that PCDH12 loss impairs cerebral organoid development and neuronal migration, leading to neurodevelopmental disorders.

This study shows that ErbB inhibition in oligodendrocytes disrupts myelination and aerobic glycolysis, impairing working memory in mice.

This study shows that CDC25B regulates G2 phase duration, affecting the balance between direct and indirect neurogenesis in the developing mouse neocortex.

This study shows p27 represses SOX2 and its downstream targets to regulate cell cycle exit in adult neurogenesis and oligodendrogenesis.

This study shows that both GEF domains of the Trio protein are essential for proper tangential migration of GABAergic interneurons, with GEFD2 playing a dominant role.

This study uses patient-derived cerebral organoids to show that MOPD I mutations cause disrupted mitotic spindle orientation, leading to premature neurogenesis and cortical layering defects.

This study benchmarks brain organoid gene co-expression patterns against fetal corticogenesis to assess their alignment with in vivo development.

This study investigates how Notch-Wnt signaling modulation affects reactive astrocyte responses after brain injury, revealing new insights into their reparative mechanisms.

The paper investigates the role of the protooncogene Ski in regulating the neuron-glia switch during mammalian cerebral cortex development and identifies its interaction with the BMP signaling pathway.

This study shows prenatal stress increases neural stem cell proliferation in adult male mice without affecting cell survival or migration, and identifies molecular mechanisms involving MAPK signaling and glomerular layer disorganization.

This study shows that Imp promotes exit from quiescence in Drosophila type II neuroblasts, independent of Syncrip, and relates to its role in promoting proliferation.

This study identifies St18 as a transcriptional determinant specifying projection neuron identity in the MGE lineage and shows its role in regulating migration and morphology of GPe neurons.