Neurogenesis and neuroplasticity mechanisms

This study uses single-cell RNA-seq to show that mouse retinal ganglion cell precursors diversify into discrete types through gradual fate restriction after mitosis.

This study shows that human spinal cord differentiation in vitro is faster than in vivo and stalls when grafted into a different species, highlighting the role of extrinsic signals.

The paper uses single-cell RNA-seq and enhancer editing to study thalamic nuclei formation in mice, revealing lineage-specific gene expression programs and their role in neurodevelopmental disorders.

This study uses single-cell RNA sequencing to reveal transcriptional heterogeneity in ventricular zone cells of the embryonic mouse forebrain, showing spatial and temporal gene expression differences.

This study shows that tissue-wide genetic effects override cell-intrinsic gene function in cortical neuron migration using MADM and single-cell analysis.

The paper identifies a conserved myelination mechanism in oligodendrocytes that forms paranodal bridges, enabling extended myelin sheaths along axons, which degenerate more frequently with age.

This study identifies the role of Sil in regulating timely Schwann cell division during migration, which is essential for myelination via the Laminin/cAMP pathway.

This study shows OPCs engulf synaptic inputs in a microglia-dependent manner during experience-dependent plasticity in the mouse visual cortex.

This study shows interferon regulates stem cell function across all ages by controlling mTOR and cell cycle, with beneficial effects in youth and harmful effects in aging brains.

This study shows that Pax6 limits the competence of developing cortical progenitors to respond to morphogens, preventing inappropriate lineage generation.

This study investigates the role of NCAM2 in regulating adult neurogenesis and neuronal differentiation by analyzing its effects on radial glial progenitors in the dentate gyrus and during corticogenesis.

This study identifies YME1L as a mitochondrial protease that regulates metabolic state transitions in adult neural stem cells, ensuring self-renewal and preventing premature differentiation.

The paper maps cell fate decisions in human developing neocortex progenitors, showing abundant direct neurogenesis bypassing intermediate progenitors.

The paper shows that miR-200a regulates mesodermal cell fate during spinal cord regeneration by repressing brachyury expression in axolotls.

The paper shows that clusters of Neurofascin A on axons predict node of Ranvier positions before myelination, independent of myelin sheath growth.

This study uses iterative immunofluorescence imaging to analyze age-related changes in the dentate gyrus niche, identifying reorganization and microenvironmental changes affecting neurogenesis in mice.

This study uses cerebral organoids to show that TSC2 mutations cause over-proliferation of caudal late interneuron progenitors, leading to Tuberous Sclerosis Complex.

The paper shows that IGF2 promotes differentiation of adult NSCs by inducing Cdkn1c expression, which drives cell cycle exit and terminal differentiation into astrocytes, neurons, and oligodendrocytes.

The paper isolates side populations from adult neurogenic niches and identifies them as endothelial cells rather than neural stem cells.

This study identifies a subpopulation of astrocyte progenitors in the neonatal brain regulated by Sonic hedgehog signaling, contributing to cortical astrocyte development.

This study identifies Yap1 as a regulator of adult neural stem cell activation, showing that its gain-of-function mutant promotes cell cycle entry and aberrant differentiation while wild-type Yap1 does not.

This study shows that prenatal stress impairs pattern separation in adult mice, potentially contributing to cognitive deficits and behaviors similar to psychiatric disorders.

This study shows that WDR81 loss of function disrupts endosomal trafficking of EGFR, reduces MAP kinase activation, and causes microcephaly by impairing radial glial progenitor proliferation.

The paper shows that the embryonic brain and scalp tissues mechanically interact, with the scalp recoiling to confine and fold the brain during development.

This study investigates interneuron migration defects in Timothy syndrome using human forebrain assembloids and identifies pharmacological targets to rescue migration abnormalities.

The paper shows that modulating the Sonic Hedgehog pathway in trisomic NPCs rescues gene expression dysregulation associated with Down syndrome.

This study identifies Klf9 as a transcriptional regulator that suppresses symmetric self-renewal of radial-glial neural stem cells in the adult hippocampus.

This study shows that Lin28a regulates adult hippocampal neurogenesis by responding to Wnt signals, and its decline contributes to aging-related cognitive impairments.

The paper shows that vision selectively drives the specification of upper-layer glutamatergic cell types in the mouse visual cortex through gene expression regulation.

The paper shows that EAAT1 facilitates glutamate-induced self-renewal of adult hippocampal NSCs through lipogenesis, highlighting a non-canonical mechanism of niche sensing.