Hans‐Georg Sprenger

The paper constructs a multi-tissue lysosomal metabolite atlas in mice, revealing age-related accumulation of glycerophosphodiesters and cystine, linked to lysosomal storage disorders, and shows caloric restriction mitigates these changes in some tissues.

This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.

This study maps zinc-regulated cysteine sites in the human proteome, identifies cancer dependencies, and reveals a mechanism of zinc-induced cytotoxicity in lung cancers.

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.

This study identifies YME1L as a mitochondrial protease that regulates metabolic state transitions in adult neural stem cells, ensuring self-renewal and preventing premature differentiation.