Cellular transport and secretion

This paper develops optogenetic systems to precisely control nanoscale membrane curvature in live cells using engineered BAR domain proteins.

The paper studies a minimal Rab5 activation network to show how positive feedback leads to bistable switching and how controlling inactive Rab5 populations shapes network responses.

This study investigates the role of Rit2 GTPase in PKC-stimulated dopamine transporter (DAT) endocytosis in DAergic terminals, revealing region- and sex-specific differences.

This paper identifies biallelic TANGO1 mutations causing a novel syndromal collagenopathy in humans, leading to multiple systemic abnormalities.

This study shows that nicotine exposure and neuronal activity alter Golgi membrane distribution in neurons, affecting local trafficking and potentially contributing to addiction.

This study systematically analyzes Rab GTPase function in Drosophila neurons, revealing that some Rabs are critical for robustness to environmental challenges despite being viable in null mutants.

The paper investigates the mechanisms and organization of clathrin transport and presynaptic targeting in neurons, revealing stable transport-packets and their role in synaptic clathrin organization.

This study shows that Syt1 oligomerisation is essential for clamping spontaneous and asynchronous neurotransmitter release, revealing a mechanism for regulating release modes.

This study identifies multiple Rab GTPases required for tracheal morphogenesis in Drosophila, particularly in dorsal branches and terminal cells, through a loss-of-function screen.

This study identifies Comt/NSF as an ubiquitination substrate of Ari-1 in Drosophila neurons and shows that Ari-1 loss of function affects neurotransmitter release differently in spontaneous and evoked modes.

This study identifies Ral GTPase and the exocyst complex as regulators of axon ensheathment in Drosophila larval peripheral nerves.

This study identifies sequence-dependent trafficking pathways of GDE2 that regulate its function in neuronal differentiation and neurodegeneration.

The paper identifies a disease-causing mutation in VPS13D that disrupts adaptor binding and membrane recruitment in yeast, supporting a conserved role for the VAB domain.

This study shows Rab2 is essential for bidirectional axonal transport of DCVs and lysosomes in Drosophila, with Arl8 also playing a role in DCV transport.

This study investigates the role of Dmon1 and Rab7 in regulating GluRIIA levels at the Drosophila neuromuscular junction, showing their interaction in the endo-lysosomal pathway.

This study shows that RAB6A/A regulates mammary secretory function by controlling STAT5 activation during lactation, with implications for transport pathways in epithelial tissues.

This study investigates the role of PHETA1/2 in zebrafish, showing that their deficiency causes renal and craniofacial defects, and links a patient variant to disease pathogenesis.

This study shows that Vps54 regulates Drosophila neuromuscular junction development and postsynaptic density composition through Rab7-dependent endosomal trafficking.

This study investigates the independent yet synergistic roles of Synaptotagmin-1 and Complexin in calcium-regulated neuronal exocytosis using a reconstituted single-vesicle fusion assay.

This study identifies IRSp53's role in shaping the plasma membrane and controlling polarized transport during epithelial morphogenesis by regulating apical lumen formation and polarity determinants.

This study identifies SNX4 as a novel synaptic protein through localization and functional analysis in neurons.

This study shows that Arfgef1 haploinsufficiency in mice reduces dendritic surface GABAAR and alters endosome composition, leading to increased seizure susceptibility.

This study identifies SorCS1's role in maintaining axonal surface polarization of neurexin by regulating its trafficking and endosomal sorting.

The paper identifies PKCα-dependent interactions between otoferlin and calbindin in inner hair cells, suggesting a role in regulating endocytosis through Ca2+-dependent signaling complexes.

This study shows that restoring VPS35 in the hippocampus of mice with chronic neuronal VPS35 depletion rescues APP cleavage and glutamate receptor levels, and reduces glial activation similar to Alzheimer's disease.

This study investigates how phosphatidylinositol 4,5 bisphosphate (PIP2) influences the cis and trans interactions of synaptotagmin 1's C2 domains through membrane reconstitution and spin labeling.

This paper determines the structure of the Syt1-SNARE complex on lipid membranes using cryo-electron microscopy to elucidate how Syt1 clamps and activates SNARE-mediated fusion through Ca2+ and Mg2+ dependent interactions.

The paper examines the genetic diversity of CHC22 clathrin and its impact on glucose metabolism, finding that a variant is less effective at controlling GLUT4 traffic and is more common in farming populations.

This study shows Piccolo is essential for synaptic vesicle recycling through Pra1 and Rab5, linking its dysfunction to neurological disorders.

The paper demonstrates that membrane tension, regulated by ILV formation, negatively feedbacks to control ESCRT-III activity in vitro, with potential implications for in vivo functions.