Philipe R. F. Mendonça

The paper shows that synaptic release probability varies across synapses but remains constant overall due to balanced facilitation and depression.

This study uses smFRET to analyze GluN1 conformational changes in NMDA receptors with different GluN2 subunits, revealing subtype-specific allosteric control mechanisms.

This paper develops a chemogenetic method to irreversibly activate K2P channels, enabling studies of their function and potential therapeutic applications.

The paper quantifies asynchronous glutamate exocytosis in synapses, showing it is enhanced in low release probability synapses and more widely dispersed than synchronous release.

This study shows that Syt1 oligomerisation is essential for clamping spontaneous and asynchronous neurotransmitter release, revealing a mechanism for regulating release modes.