Protease and Inhibitor Mechanisms

The paper introduces PAA, a toolkit for analyzing protease activity data, offering preprocessing, visualization, and machine learning tools to standardize analysis across in vitro and in vivo assays.

This study identifies MLT-11, a protease inhibitor essential for C. elegans molting and embryogenesis, showing its role in aECM remodeling and cuticle integrity.

This study investigates the evolutionary relationship between NSP4 and GZMM, finding a closer evolutionary link between Prss57/NSP4 and Gzmm/GZMM than with other proteases.

This paper identifies ADM-2 as a negative regulator of molting in C. elegans, showing it inhibits molting by regulating LRP-1 and endocytic trafficking.

The paper identifies ADAMTS7 substrates and cleavage sites using TAILS, revealing potential biomarkers for coronary artery disease.

This study constructs a comprehensive phylogeny of 6000 serpin sequences across all kingdoms of life, showing convergent evolution rather than horizontal gene transfer for the central hub proteins.

The paper identifies cleavage sites of ectodomain shedding in 10 human cell lines using mass spectrometry and finds 411 cleavage sites on 132 membrane proteins.

The paper identifies potential antibody epitopes in MMP-15 using bioinformatics tools, highlighting conserved and divergent regions for therapeutic targeting.

The paper investigates genetic interactions between ADAMTS proteases and basement membrane proteins in C. elegans gonad development, identifying suppressor mutations that affect both mig-17 and gon-1 mutants.

This study examines MMP-2 and MMP-9 expression in rat small intestine mucosa during intrauterine and postnatal development, finding no expression in epithelium but MMP-9 in mast cells postnatally.

This study shows MMP14's basolateral localization drives apicobasal polarity changes during EMT independently of its catalytic activity in chick neural crest cells.

The paper identifies a hypomorphic MMP14 mutation in Winchester syndrome and shows its catalytic activity determines disease severity using in vitro and zebrafish models.

The paper shows ADAM17 is the main enzyme that removes the outer part of the AREG protein, which is important for skin health and cancer.